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Baseline Anti-Dengue IgG Seroprevalence in a Pediatric Brazilian Population Before TAK-003 Vaccination

Amanda Maria Miguel Bortuluzi1, Paulo César Pereira Dos Santos2, Luana Clemm Kuhnen Anschau1

  • 1Post Graduate Program in Health Sciences, Federal University of Grande Dourados, Dourados, Brazil.

The American Journal of Tropical Medicine and Hygiene
|February 9, 2026
PubMed

Insights

Dengue IgG seroprevalence in Brazilian children aged 4-16 was 20.5%, increasing with age. Baseline data are crucial for guiding the TAK-003 vaccine strategy and monitoring risks.

Area of Science:

  • Tropical Medicine
  • Immunology
  • Public Health

Background:

  • Dengue is a significant public health issue in Brazil, causing frequent outbreaks.
  • The TAK-003 vaccine presents a potential method for dengue control, especially in pediatric populations.

Purpose of the Study:

  • To assess the baseline seroprevalence of anti-dengue IgG antibodies in children and adolescents in Dourados, Brazil.
  • To inform the implementation and monitoring of the TAK-003 dengue vaccine.

Main Methods:

  • Cross-sectional study involving 643 children and adolescents (4-16 years).
  • Analysis of anti-dengue IgG seroprevalence using ELISA on capillary blood samples.
  • Collection of sociodemographic data via questionnaires.

Main Results:

  • Overall anti-dengue IgG seroprevalence was 20.5%.
  • Seropositivity significantly increased with age, from 13.4% (4-8 years) to 27.7% (13-16 years).
  • Male sex was associated with lower IgG levels.

Conclusions:

  • Age-specific seroprevalence indicates cumulative dengue virus exposure in children and adolescents.
  • Baseline seroprevalence data are essential for effective dengue vaccination strategies, assessing vaccine efficacy, and managing risks like antibody-dependent enhancement.

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