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Role of pyroptosis in lung cancer: Molecular mechanisms and therapeutic implications

Ke Zhang1, Xiao-Han Zhang1, Xue-Chun Qu1

  • 1Henan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, School of Stomatology, Henan University, Kaifeng, Henan 475004, China.

Cellular Signalling
|February 9, 2026
PubMed

Insights

Pyroptosis, a cell death pathway, offers new strategies for overcoming drug resistance in lung cancer. Activating pyroptosis may improve early detection, metastasis prediction, and overall treatment outcomes for this fatal disease.

Area of Science:

  • Oncology
  • Cell Biology
  • Molecular Medicine

Background:

  • Lung cancer is a leading cause of cancer-related mortality globally.
  • Advanced lung cancer often develops drug resistance, leading to poor patient prognosis.
  • Pyroptosis, a programmed cell death pathway involving gasdermins, presents potential therapeutic avenues.

Purpose of the Study:

  • To summarize lung cancer development, metastasis, and cell death prediction.
  • To explore the role of pyroptosis in overcoming drug resistance.
  • To provide a basis for novel lung cancer treatment strategies targeting pyroptosis.

Main Methods:

  • Review of current literature on lung cancer progression and cell death mechanisms.
  • Analysis of the role of gasdermin-mediated pyroptosis pathways.
  • Investigation of strategies to modulate pyroptosis for therapeutic benefit.

Main Results:

  • Genes related to cell proliferation aid in early lung cancer detection and metastasis prediction.
  • Targeted strategies can regulate pyroptosis to inhibit tumor growth.
  • Specific molecules can serve as prognostic markers in lung cancer.

Conclusions:

  • Activating pyroptosis presents a promising strategy for overcoming drug resistance in lung cancer.
  • Understanding pyroptosis mechanisms is crucial for developing novel therapeutic approaches.
  • Targeting pyroptosis could significantly improve lung cancer treatment and patient outcomes.
Keywords:
Drug resistanceDual functionLung cancerNovel treatment strategyPyroptosis

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