Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Uncertainty in Measurement: Accuracy and Precision03:37

Uncertainty in Measurement: Accuracy and Precision

104.1K
Scientists typically make repeated measurements of a quantity to ensure the quality of their findings and to evaluate both the precision and the accuracy of their results. Measurements are said to be precise if they yield very similar results when repeated in the same manner. A measurement is considered accurate if it yields a result that is very close to the true or the accepted value. Precise values agree with each other; accurate values agree with a true value. 
104.1K
Accuracy and Precision01:52

Accuracy and Precision

15.6K
Scientists typically make repeated measurements of a quantity to ensure the quality of their findings and to evaluate both the precision and the accuracy of their results. Measurements are said to be precise if they yield very similar results when repeated in the same manner. A measurement is considered accurate if it yields a result that is very close to the true or the accepted value. Precise values agree with each other; accurate values agree with a true value.  Highly accurate...
15.6K
Inertia Tensor01:24

Inertia Tensor

1.2K
The concept of the inertia tensor is employed to depict the mass distribution and rotational inertia of a solid or rigid object. This tensor is expressed through a three-by-three matrix. Each component within this matrix corresponds to varying moments of inertia about specific axes.
The diagonal components of the inertia tensor matrix represent the moments of inertia concerning the principal axes of the object. These primary axes are defined as the axes where the object experiences the least...
1.2K
Biodiversity and Human Values01:24

Biodiversity and Human Values

17.1K
Human civilization relies on biodiversity in many ways. Sudden changes in species biodiversity result in environmental changes that can modify weather patterns and therefore human civilizations.
17.1K
Diffusion01:12

Diffusion

221.5K
Diffusion is the passive movement of substances down their concentration gradients—requiring no expenditure of cellular energy. Substances, such as molecules or ions, diffuse from an area of high concentration to an area of low concentration in the cytosol or across membranes. Eventually, the concentration will even out, with the substance moving randomly but causing no net change in concentration. Such a state is called dynamic equilibrium, which is essential for maintaining overall...
221.5K
Professional Values01:29

Professional Values

10.8K
Nurses are responsible for caring for patients during birth, death, illness, and healing. Professional values guide the decisions and actions that nurses make in their careers. If nurses know the decisions and actions to take, providing patients with exceptional care is possible.
The values that are the foundation of the nursing profession are altruism, autonomy, human dignity, and social justice.
First, altruism refers to the concern for the welfare and well-being of others without personal...
10.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ventricular volumetry in relation to clinical response and overdrainage after shunt surgery in idiopathic normal-pressure hydrocephalus: a three-year prospective study.

Fluids and barriers of the CNS·2026
Same author

Characterizing the MRI signature of hippocampal sclerosis of aging.

Alzheimer's research & therapy·2026
Same author

Efficacy and target engagement of dopamine agonist pramipexole for anhedonic depression: a randomized placebo-controlled trial.

Nature medicine·2026
Same author

The Role of Dendritic Spines in Water Exchange Measurements With Diffusion MRI: Double Diffusion Encoding and Free-Waveform MRI.

NMR in biomedicine·2026
Same author

[Brain imaging in cognitive disorders - from diagnosis to treatment and monitoring].

Lakartidningen·2026
Same author

The Role of Clinical, Plasma, and Imaging Biomarkers in Assessing Future Dementia Risk in Individuals With Subjective Cognitive Decline.

Neurology·2026
Same journal

CT Evaluation of Osseous Trauma at the Craniocervical Junction: A Pattern-Based Overview.

AJNR. American journal of neuroradiology·2026
Same journal

Comprehensive Structural MRI Phenotyping in <i>Oligophrenin 1-</i>Related Disorder Reveals Characteristic Brain Malformations.

AJNR. American journal of neuroradiology·2026
Same journal

ASNR-ESNR White Paper on Sustainability in Neuroradiology.

AJNR. American journal of neuroradiology·2026
Same journal

Intracranial Atherosclerotic Disease Distribution Across Circle of Willis Segments: Insights from CREST-H.

AJNR. American journal of neuroradiology·2026
Same journal

Regional Cerebral Blood Flow Patterns on ASL in Subacute Sclerosing Panencephalitis: Quantitative Analysis and Clinical Correlation.

AJNR. American journal of neuroradiology·2026
Same journal

Improved Diagnostic Certainty of Photon-Counting CT Myelography Compared with Energy-Integrating CT for CSF-Venous Fistulas in Spontaneous Intracranial Hypotension.

AJNR. American journal of neuroradiology·2026
See all related articles

Related Experiment Video

Updated: Feb 11, 2026

Diffusion Tensor Magnetic Resonance Imaging in Chronic Spinal Cord Compression
07:00

Diffusion Tensor Magnetic Resonance Imaging in Chronic Spinal Cord Compression

Published on: May 7, 2019

9.4K

Balancing Accuracy and Precision: Optimal b-Values for Diffusion Tensor Imaging along the Perivascular Space.

Nelly Vuong1,2, Samo Lasič3, Sara Hall4,5

  • 1From the Diagnostic Radiology (N.V., S.L., D.v.W., M.N., C.G.), Department of Clinical Sciences, Faculty of Medicine, Lund University, Lund, Sweden nelly.vuong@med.lu.se.

AJNR. American Journal of Neuroradiology
|February 9, 2026
PubMed
Summary
This summary is machine-generated.

The optimal b-value for Diffusion Tensor Imaging Along the Perivascular Space (DTI-ALPS) is approximately 700 s/mm², not the commonly used 1000 s/mm². This finding improves glymphatic function assessment in neurodegenerative diseases.

More Related Videos

Tracking the Mammary Architectural Features and Detecting Breast Cancer with Magnetic Resonance Diffusion Tensor Imaging
15:48

Tracking the Mammary Architectural Features and Detecting Breast Cancer with Magnetic Resonance Diffusion Tensor Imaging

Published on: December 15, 2014

23.2K
Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

29.3K

Related Experiment Videos

Last Updated: Feb 11, 2026

Diffusion Tensor Magnetic Resonance Imaging in Chronic Spinal Cord Compression
07:00

Diffusion Tensor Magnetic Resonance Imaging in Chronic Spinal Cord Compression

Published on: May 7, 2019

9.4K
Tracking the Mammary Architectural Features and Detecting Breast Cancer with Magnetic Resonance Diffusion Tensor Imaging
15:48

Tracking the Mammary Architectural Features and Detecting Breast Cancer with Magnetic Resonance Diffusion Tensor Imaging

Published on: December 15, 2014

23.2K
Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

29.3K

Area of Science:

  • Neuroimaging
  • Neuroscience
  • Biomedical Engineering

Background:

  • The glymphatic system clears waste from the brain, and its dysfunction is linked to neurodegenerative diseases.
  • Diffusion Tensor Imaging Along the Perivascular Space (DTI-ALPS) is a method to assess glymphatic function, but its reliability is debated.
  • The optimal b-value for DTI-ALPS is currently unknown.

Purpose of the Study:

  • To determine the optimal b-value for DTI-ALPS.
  • To investigate the influence of b-value on the accuracy and precision of glymphatic function assessment.

Main Methods:

  • Simulations were performed to analyze the impact of b-value on ALPS index bias, precision, and effect size.
  • DTI-ALPS was applied to 194 participants across four groups: healthy controls, Parkinson's disease, Parkinson's disease dementia, and progressive supranuclear palsy.
  • ALPS indices were calculated using regions of interest on specific fiber tracts, and group differences were analyzed across various b-values.

Main Results:

  • In vivo ALPS indices were higher at lower b-values (250-500 s/mm²) compared to 1000 s/mm².
  • Simulations revealed a bias-variance trade-off, with intermediate b-values (≈700 s/mm²) maximizing the effect size.
  • Lower ALPS indices were observed in Parkinson's disease dementia and progressive supranuclear palsy patients compared to controls, with variations across b-values.

Conclusions:

  • The standard b-value of 1000 s/mm² is suboptimal for DTI-ALPS.
  • Intermediate b-values around 700 s/mm² appear more suitable for assessing perivascular space diffusion.
  • Further optimization of DTI-ALPS acquisition parameters is recommended for improved glymphatic function evaluation.