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Hypophosphataemia in severe burns.

H Nordström, S Lennquist, B Lindell

    Acta Chirurgica Scandinavica
    |January 1, 1977
    PubMed
    Summary
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    Severe burns can cause a significant drop in serum phosphate levels, particularly between days 3-9 post-injury. This hypophosphatemia may be linked to fatal outcomes in critically burned patients.

    Area of Science:

    • Biochemistry
    • Trauma Medicine
    • Clinical Research

    Background:

    • Severe burns represent a critical injury with complex metabolic disturbances.
    • Phosphate homeostasis is vital for cellular function and energy metabolism.

    Purpose of the Study:

    • To investigate the pattern and significance of serum and urinary phosphate levels in severely burned patients.
    • To explore the potential correlation between hypophosphatemia and patient outcomes.

    Main Methods:

    • Retrospective analysis of 17 severely burned patients.
    • Monitoring of serum and urinary phosphate levels post-burn injury.

    Main Results:

    • A consistent decrease in serum phosphate was observed between days 3 and 9.

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  • The lowest mean serum phosphate level was 0.57 +/- 0.2 mmol/l on day 5.
  • Patients with the lowest serum phosphate values (<0.32 mmol/l) had a higher mortality rate.
  • Phosphate depletion appeared to be of prerenal origin.

    • Conclusions:

    • Hypophosphatemia is a common finding in severe burn patients.
    • Severely low serum phosphate levels may indicate a poor prognosis and contribute to mortality.
    • Phosphate depletion in burns warrants further investigation.