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Author Spotlight: Advancements in Stem Cell Regenerative Therapy Through Photobiomodulation
Published on: April 5, 2024
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Systemic Effect of Thermo-Photobiomodulation on Mesenchymal Stem Cells
V I Yusupov1, R K Chailakhyan2, A G Grosheva2
1National Research Centre "Kurchatov Institute", Moscow, Russia.
Bulletin of Experimental Biology and Medicine
|February 9, 2026
Summary
Thermo-photobiomodulation (TPBM) temporarily increases mesenchymal stem cells (MSCs) in bone marrow and spleen. Repeated TPBM sessions enhance MSC growth in injured areas, aiding tissue regeneration.
Area of Science:
- Biomedical Engineering
- Regenerative Medicine
- Stem Cell Biology
Background:
- Mesenchymal stem cells (MSCs) are crucial for tissue repair and regeneration.
- Photobiomodulation is an emerging therapeutic approach for tissue healing.
- Understanding the systemic effects of therapies on MSCs is vital for clinical translation.
Purpose of the Study:
- To investigate the systemic effects of thermo-photobiomodulation (TPBM) on MSCs.
- To evaluate the influence of repeated TPBM sessions in vivo.
- To assess the impact of localized laser irradiation on MSC distribution.
Main Methods:
- Rats underwent localized laser irradiation (970 nm) of tibial bone marrow.
- MSC counts were analyzed in bone marrow and spleen post-irradiation.
- Comparisons were made between single and repeated TPBM sessions.
Main Results:
- TPBM significantly increased MSC counts temporarily in both irradiated and distant tissues.
- Repeated TPBM sessions demonstrated enhanced MSC growth in the injured area compared to single sessions.
- The study observed systemic mobilization and regulation of MSCs by TPBM.
Conclusions:
- TPBM effectively influences MSC distribution and proliferation systemically.
- Repeated TPBM sessions show potential for enhanced regenerative capacity.
- These findings support TPBM as a promising strategy for cell therapy and tissue regeneration.
Keywords:
bone marrow mesenchymal stem cellscell coloniesfractional thermal laser exposurestimulation of bone marrow MSCsthermo-photobiomodulationMore Related Videos
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