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Updated: Feb 11, 2026
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Anastasis: Reality or Fiction?
Y S Kim1, K V Kovalskaya1, S L Malov2
1Institute of Biomedical Chemistry, Moscow, Russia.
Bulletin of Experimental Biology and Medicine
|February 9, 2026
Summary
Tumor cells resist apoptosis and can reverse cell death, a process called anastasis. Mesenchymal stem cells (MSCs) showed anastasis after ethanol or doxorubicin treatment, but not staurosporine.
Area of Science:
- Cell biology
- Cancer research
- Stem cell biology
Background:
- Tumor cells evade apoptosis for survival and metastasis.
- Anastasis describes the reversibility of cell death.
- Mesenchymal stem cells (MSCs) exhibit resistance to apoptosis.
Purpose of the Study:
- To investigate anastasis in human mesenchymal cells.
- To determine the effect of cell death inducers on anastasis.
Main Methods:
- Exposure of human liver MSCs, placental MSCs, and skin fibroblasts to ethanol, staurosporine, or doxorubicin.
- Observation of cell morphology and proliferation post-treatment.
Main Results:
- Mesenchymal cells demonstrated anastasis upon treatment with non-lethal ethanol doses.
- Low concentrations of doxorubicin also induced reversible cell death (anastasis).
- Non-lethal staurosporine concentrations resulted in irreversible cytostatic effects, not anastasis.
Conclusions:
- Mesenchymal cells can undergo anastasis, reversing cell death under specific conditions.
- The reversibility of cell death is dependent on the inducer and its concentration.
- Anastasis may represent a survival mechanism in mesenchymal cells, distinct from staurosporine-induced cytostasis.
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