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Anastasis: Reality or Fiction?

Y S Kim1, K V Kovalskaya1, S L Malov2

  • 1Institute of Biomedical Chemistry, Moscow, Russia.

Bulletin of Experimental Biology and Medicine
|February 9, 2026
PubMed

Insights

Tumor cells resist apoptosis and can reverse cell death, a process called anastasis. Mesenchymal stem cells (MSCs) showed anastasis after ethanol or doxorubicin treatment, but not staurosporine.

Area of Science:

  • Cell biology
  • Cancer research
  • Stem cell biology

Background:

  • Tumor cells evade apoptosis for survival and metastasis.
  • Anastasis describes the reversibility of cell death.
  • Mesenchymal stem cells (MSCs) exhibit resistance to apoptosis.

Purpose of the Study:

  • To investigate anastasis in human mesenchymal cells.
  • To determine the effect of cell death inducers on anastasis.

Main Methods:

  • Exposure of human liver MSCs, placental MSCs, and skin fibroblasts to ethanol, staurosporine, or doxorubicin.
  • Observation of cell morphology and proliferation post-treatment.

Main Results:

  • Mesenchymal cells demonstrated anastasis upon treatment with non-lethal ethanol doses.
  • Low concentrations of doxorubicin also induced reversible cell death (anastasis).
  • Non-lethal staurosporine concentrations resulted in irreversible cytostatic effects, not anastasis.

Conclusions:

  • Mesenchymal cells can undergo anastasis, reversing cell death under specific conditions.
  • The reversibility of cell death is dependent on the inducer and its concentration.
  • Anastasis may represent a survival mechanism in mesenchymal cells, distinct from staurosporine-induced cytostasis.
Keywords:
anastasisapoptosiscell deathmesenchymal stem cellsskin fibroblasts

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