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Related Concept Videos

Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Targeted Cancer Therapies02:57

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Gene Therapy00:59

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Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
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Group therapy is a sociocultural approach to psychological treatment, where individuals with shared psychological challenges come together under the guidance of a mental health professional. This therapeutic modality offers unique opportunities for individuals to connect, share, and grow within the context of a supportive group. By fostering mutual understanding and collaboration, group therapy can address a range of psychological concerns effectively, often complementing or surpassing the...
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Behavior Therapy01:22

Behavior Therapy

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Behavior therapy incorporates diverse techniques rooted in classical conditioning principles to address maladaptive behaviors and anxiety disorders. These methods aim to reduce avoidance behaviors, foster adaptive coping mechanisms, and alter associations between stimuli and responses, making them effective in a wide range of therapeutic contexts.
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Drug Therapy01:28

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The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
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Related Experiment Video

Updated: Feb 11, 2026

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STING-Activating nanoplatforms for image-guided sonodynamic cancer therapy.

Lingpu Zhang1, Delong Huang2, Jia Li3

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Molecular Cancer
|February 10, 2026
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A novel nanodrug combines imaging, therapy, and immune response for breast cancer. This multimodal platform enables precise tumor monitoring and enhanced anti-tumor effects via ultrasound activation.

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Nuclear imagingPolymer nanocarriersSonodynamic therapyTheranostic nanodrugcGAS-STING

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Area of Science:

  • Biomedical Engineering
  • Nanomedicine
  • Cancer Therapy

Background:

  • Precision cancer treatment requires real-time monitoring, a current challenge.
  • Nanomedicine offers integrated nano-platforms for enhanced tumor diagnosis and treatment.
  • Ultrasound (US) activated therapies show promise for targeted cancer treatment.

Purpose of the Study:

  • To develop a multimodal diagnostic nanodrug for immuno-sonodynamic therapy targeting breast cancer.
  • To integrate sonosensitizers, STING agonists, and radionuclides for combined diagnosis and therapy.
  • To enable real-time monitoring and precise therapeutic intervention in breast cancer models.

Main Methods:

  • Created a nanodrug (⁹⁹ᵐTc-NPᴬᴵᴱ-MSA) with aggregation-induced luminescence properties.
  • Utilized US activation to generate reactive oxygen species and trigger the cGAS-STING pathway.
  • Incorporated ⁹⁹ᵐTc for SPECT/CT and fluorescence imaging, and released STING agonist MSA-2.
  • Evaluated anti-tumor effects and immunomodulation in vitro and in vivo.

Main Results:

  • US activation generated reactive oxygen species, causing DNA and mitochondrial damage.
  • The nano-platform successfully activated the cGAS-STING pathway and released MSA-2.
  • ⁹⁹ᵐTc facilitated precise tumor targeting and monitoring via imaging modalities.
  • Significant anti-tumor effects and immunomodulation were observed in vitro and in vivo.

Conclusions:

  • The developed nanodrug ⁹⁹ᵐTc-NPᴬᴵᴱ-MSA is effective for immuno-sonodynamic therapy in breast cancer.
  • This multimodal platform offers precise tumor diagnosis, monitoring, and treatment capabilities.
  • The strategy presents a novel approach for advanced, image-guided cancer therapy and immunomodulation.