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Flexible Bioactive Glass-Fiber-Reinforced Recombinant Collagen Sponge for Versatile Hemostasis, Antibacterial
Zhe Fan1,2,3, Meng Li4, Kehan Cai1
1Department of Orthopedic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Advanced Healthcare Materials
|February 10, 2026
Summary
A novel composite sponge made of recombinant human-like collagen and copper-doped bioactive glass fibers effectively stops bleeding and promotes skin healing. This advanced wound dressing accelerates coagulation, reduces inflammation, and enhances tissue regeneration for improved patient outcomes.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Wound Healing Research
Background:
- Achieving rapid hemostasis and functional skin regeneration simultaneously presents a significant challenge in wound care.
- Existing treatments often struggle to balance bleeding control with effective tissue repair.
Purpose of the Study:
- To engineer a flexible composite sponge combining recombinant human-like collagen (RHC) with copper-doped bioactive glass fibers (CuBGF).
- To evaluate the hemostatic, regenerative, antibacterial, and anti-inflammatory properties of the developed CuBGF-RHC sponge for advanced wound management.
Main Methods:
- Fabrication of a porous, hydrophilic, and mechanically robust CuBGF-RHC composite sponge.
- In vitro assessment of fibroblast proliferation, wound closure, reactive oxygen species levels, and macrophage polarization.
- In vitro antibacterial assays against Staphylococcus aureus and Escherichia coli.
- In vitro hemostatic assays measuring coagulation time and platelet adhesion.
- In vivo evaluation in rat femoral vein bleeding models and full-thickness skin wound models.
- Transcriptomic analysis to investigate underlying molecular pathways.
Main Results:
- The CuBGF-RHC sponge demonstrated enhanced fibroblast proliferation (∼200%), accelerated wound closure (98.7% in 48h), reduced oxidative stress, and suppressed pro-inflammatory macrophage polarization (70.2% to 11.9%).
- Significant antibacterial activity was observed, nearly eliminating bacterial colonies.
- Hemostatic assays showed reduced clotting times (6.7 min vs. >10 min for control) and increased platelet adhesion (41.9%).
- In vivo studies confirmed reduced hemostasis time (198.3 s) and blood loss (1.33 g) in bleeding models.
- Full-thickness wounds showed >93% closure by day 14, with enhanced collagen remodeling and restored adnexal structures.
- Transcriptomic analysis indicated regulation of key pathways including extracellular matrix remodeling, angiogenesis, and inflammation.
Conclusions:
- The engineered CuBGF-RHC sponge effectively integrates structural and biochemical properties for rapid hemostasis and functional skin regeneration.
- This composite material shows significant potential for translational applications in advanced wound management.
- The study highlights a promising biomaterial strategy for addressing complex wound healing challenges.
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