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Animal Models of Lupus Nephritis: Current Status and Future Perspectives
Lihe Sheng1, Niqin Xiao1, Bingbing Chen1
1Yunnan University of Chinese Medicine, Kunming, China.
International Journal of Rheumatic Diseases
|February 10, 2026
Summary
This review explores lupus nephritis (LN) animal models, crucial for understanding systemic lupus erythematosus (SLE) and developing treatments. It compares various models to guide future research and therapeutic strategies.
Area of Science:
- Nephrology
- Immunology
- Translational Medicine
Background:
- Lupus nephritis (LN) is a severe complication of systemic lupus erythematosus (SLE).
- Understanding LN pathogenesis is vital for drug discovery and therapeutic evaluation.
- Animal models are essential tools for studying LN.
Purpose of the Study:
- To comprehensively review existing animal models for lupus nephritis.
- To assess the validity and effectiveness of various LN models.
- To provide guidance for selecting appropriate models in LN research.
Main Methods:
- Review of common spontaneous, inducible, humanized, and knockout LN animal models.
- Comparative analysis of model characteristics and effectiveness.
- Assessment of model validity in preclinical research.
Main Results:
- Diverse LN animal models exist, each with unique characteristics.
- Model selection requires careful consideration of research objectives.
- Comparative analysis highlights strengths and limitations of different models.
Conclusions:
- Appropriate selection of LN animal models is critical for successful research.
- This review offers valuable insights for preclinical studies in lupus nephritis.
- Further research is needed to refine and validate existing LN models.
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