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Drug Resistance in Extrapulmonary Tuberculosis in Korea, 2010-2019: A Comparison With Pulmonary Tuberculosis
Saerom Kim1,2, Doosoo Jeon3,4, Taehoon Lee5
1Department of Internal Medicine, Pusan National University Hospital, Busan, Korea.
Journal of Korean Medical Science
|February 10, 2026
Summary
Extrapulmonary tuberculosis (EPTB) is increasing, with lower drug resistance rates compared to pulmonary tuberculosis (PTB). Continuous monitoring of drug resistance trends in EPTB is crucial for effective patient management.
Area of Science:
- Microbiology
- Infectious Diseases
- Public Health
Background:
- Investigated drug resistance patterns in extrapulmonary tuberculosis (EPTB) patients.
- Compared EPTB drug resistance with pulmonary tuberculosis (PTB) cases.
- Analyzed trends in drug resistance over a decade in South Korea.
Purpose of the Study:
- To determine the drug resistance status and trends in EPTB patients.
- To compare drug resistance profiles between EPTB and PTB.
- To inform strategies for managing EPTB.
Main Methods:
- Retrospective analysis of phenotypic drug susceptibility testing (DST) results.
- Inclusion of culture-confirmed tuberculosis (TB) cases from seven South Korean hospitals (2010-2019).
- Comparison of EPTB and PTB patient groups (10,557 total).
Main Results:
- EPTB proportion increased among all TB cases.
- Pleura, lymph nodes, and bones/joints were common EPTB sites.
- New EPTB patients showed lower resistance rates to isoniazid (8.5%) and rifampicin (2.4%) compared to PTB.
- Multidrug/rifampicin-resistant TB (MDR/RR-TB) decreased in both groups.
Conclusions:
- Provides critical data on EPTB drug resistance in South Korea.
- Highlights the need for ongoing drug resistance surveillance in EPTB.
- Emphasizes updating drug susceptibility testing databases for improved EPTB management.
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