Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Amyloid Fibrils03:03

Amyloid Fibrils

12.0K
Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
12.0K
Amyloid Fibrils03:03

Amyloid Fibrils

6.5K
6.5K
Fibril-associated Collagen01:11

Fibril-associated Collagen

3.4K
Fibril-associated collagens are a type of collagens present in the extracellular matrix with interrupted triple helices or FACIT (Fibril-associated collagens interrupted triple-helices). FACIT help connect and attach the collagen fibrils with each other as well as with other proteins of the extracellular matrix.
For example, the type II collagen fibrils in cartilage have covalently bound type IX fibril-associated collagens at regular intervals. Other types of fibril-associated collagens are...
3.4K
Maintenance of the ES Cell State01:14

Maintenance of the ES Cell State

2.8K
The cells of the blastocyst inner cell mass only remain pluripotent for a short time. This state of pluripotency and self-renewal can be maintained in embryonic stem (ES) cell culture by adding specific chemicals or growth factors to ensure the cells can continue dividing and later differentiate into different cell types. In some cases, the cells are grown on a feeder layer of differentiated cells, which provides the growth factors and extracellular matrix components necessary for stem cell...
2.8K
Introduction to Fibroblasts01:09

Introduction to Fibroblasts

4.0K
Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...
4.0K
Self-Evaluation Maintenance Model01:29

Self-Evaluation Maintenance Model

330
The Self-Evaluation Maintenance (SEM) model offers a psychological framework to understand how individuals’ self-esteem is influenced by the achievements of others, particularly those with whom they share close personal bonds. The SEM model operates when personal rather than social identity guides individuals. Central to this model is the notion that individuals have an inherent desire to preserve a favorable self-image, which is continuously shaped by interpersonal comparisons and...
330

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mavacamten shows broad benefit in human and mouse models of MYBPC3-related hypertrophic cardiomyopathy.

Nature cardiovascular research·2026
Same author

Fibronectin-induced overactivation of α<sub>V</sub>β<sub>3</sub>-PI3K-PIP3-PDK1-ILK signaling drives aortic disease in Marfan syndrome.

Nature communications·2026
Same author

NOD1 is a key mediator of atrial myopathy in heart failure.

Theranostics·2026
Same author

OMA1 protects from liver injury and tumorigenesis during aging by controlling hepatic immunogenicity.

The EMBO journal·2026
Same author

Repurposing polyamines to prevent life-threatening arrhythmias in Short QT Syndrome type 3.

Nature communications·2026
Same author

Low-dose Empagliflozin Does Not Modify Myocardial Energetics and Function in a Large-animal Model of Hibernating Myocardium.

Journal of cardiovascular translational research·2026
Same journal

Editors and Editorial Board.

Circulation research·2026
Same journal

Cannabis Is Associated With Potentially Proatherogenic Inflammation in Youth.

Circulation research·2026
Same journal

WTAP Deficiency Promotes Podocyte PANoptosis and FSGS via SPP1 Signaling.

Circulation research·2026
Same journal

B1a Cell-IgM Axis Protects Against Hypertension by Blunting IFNγ+CD4+T Cells.

Circulation research·2026
Same journal

SBK2 Links Cardiac Stress Signaling to Mitochondrial Proteostasis.

Circulation research·2026
Same journal

Myeloid Piezo1 as a Brake on Efferocytosis and Cardiac Repair in the Infarcted Heart.

Circulation research·2026
See all related articles

Related Experiment Video

Updated: Feb 11, 2026

Transesophageal Atrial Burst Pacing for Atrial Fibrillation Induction in Rats
05:12

Transesophageal Atrial Burst Pacing for Atrial Fibrillation Induction in Rats

Published on: February 14, 2022

3.8K

Cardiac Macrophages and Fibroblasts Modulate Atrial Fibrillation Maintenance.

Ana Simon-Chica1, Jorge G Quintanilla1,2,3, Carlos Torroja4

  • 1Novel Arrhythmogenic Mechanisms Program, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain (A.S.-C., J.G.Q., M.C.-S., H.T., A.R.-R., J.M.A.-A., A.G.-E., M.M.-B., G.L.R., C.M., D.F.-R.).

Circulation Research
|February 10, 2026
PubMed
Summary
This summary is machine-generated.

Persistent atrial fibrillation (PsAF) involves distinct regional fibroblast and myeloid cell changes in areas driving the arrhythmia. Identifying these specific cell populations in driver regions offers new therapeutic targets for PsAF.

Keywords:
atrial appendageatrial fibrillationfibroblastsmacrophages

More Related Videos

Sterile Pericarditis in Aachener Minipigs As a Model for Atrial Myopathy and Atrial Fibrillation
08:56

Sterile Pericarditis in Aachener Minipigs As a Model for Atrial Myopathy and Atrial Fibrillation

Published on: September 24, 2021

3.1K
Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
08:10

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation

Published on: July 20, 2022

2.2K

Related Experiment Videos

Last Updated: Feb 11, 2026

Transesophageal Atrial Burst Pacing for Atrial Fibrillation Induction in Rats
05:12

Transesophageal Atrial Burst Pacing for Atrial Fibrillation Induction in Rats

Published on: February 14, 2022

3.8K
Sterile Pericarditis in Aachener Minipigs As a Model for Atrial Myopathy and Atrial Fibrillation
08:56

Sterile Pericarditis in Aachener Minipigs As a Model for Atrial Myopathy and Atrial Fibrillation

Published on: September 24, 2021

3.1K
Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
08:10

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation

Published on: July 20, 2022

2.2K

Area of Science:

  • Cardiovascular Biology
  • Cardiac Electrophysiology
  • Cellular and Molecular Medicine

Background:

  • Nonmyocytes play a role in atrial remodeling during persistent atrial fibrillation (PsAF).
  • Understanding fibroblast and macrophage heterogeneity in PsAF is crucial for perpetuation mechanisms.

Purpose of the Study:

  • To investigate differential features of fibroblast and macrophage populations in specific atrial regions maintaining PsAF.
  • To identify cellular drivers of PsAF in both animal models and human patients.

Main Methods:

  • Utilized pig models and humanPsAF samples, employing high-density mapping to identify driver regions.
  • Conducted flow cytometry, single-cell RNA sequencing, immunohistochemistry, and proteomics to analyze cellular composition and phenotypes.
  • Validated findings through ablation studies in pigs and clinical follow-up in human patients.

Main Results:

  • Ablation of driver regions successfully terminated PsAF in pigs and achieved high AF-freedom in humans.
  • PsAF induced a shift towards ACTA2-fibroblasts and PTX3-fibroblasts, with PTX3-fibroblasts enriched in driver regions.
  • Driver regions in both species showed enrichment of cardiac resident macrophages with profiles supporting cardiomyocyte homeostasis.

Conclusions:

  • Persistent atrial fibrillation is characterized by regional fibroblast and myeloid population changes in arrhythmia driver regions.
  • Distinctive gene signatures in these driver regions highlight potential therapeutic targets for PsAF management.