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Updated: Feb 11, 2026
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Preparation of Nanoparticles for ToF-SIMS and XPS Analysis
Published on: September 13, 2020
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SLPcalculator: a web-based tool to estimate nanoparticle heating with peak analysis and F-test
Iago López-Vázquez1,2, Yilian Fernández-Afonso3,4, Antonio Santana-Otero1
1Applied Physics Department, Universidade de Santiago de Compostela, Spain. david.serantes@usc.es.
Nanoscale
|February 10, 2026
Summary
Determining Specific Loss Power (SLP) is challenging. This study validates the Peak Analysis Method (PAM) using statistical criteria for accurate SLP calculation in magnetic hyperthermia and photothermal heating.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Materials Science
Background:
- Accurate Specific Loss Power (SLP) determination is critical for magnetic hyperthermia and photothermal heating applications.
- Current methods often rely on subjective linear range selection, leading to inconsistent results.
- Newton's-law-based approaches, like the Initial Slope Method (ISM), are widely used but have limitations.
Purpose of the Study:
- To evaluate the practical implementation of the Peak Analysis Method (PAM) for SLP determination.
- To investigate the impact of data point selection on identifying the linear regime in heating/cooling curves.
- To introduce a statistically robust and user-friendly tool for reliable SLP estimation.
Main Methods:
- Implemented the Peak Analysis Method (PAM) focusing on the linear regime around the temperature peak.
- Utilized an F-test-based statistical criterion to objectively identify the valid linear range.
- Compared SLP values obtained via PAM with those from the Initial Slope Method (ISM).
Main Results:
- Objective determination of the linear range significantly impacts SLP values.
- PAM, guided by statistical criteria, provides more robust and reproducible SLP estimations compared to arbitrary time windows.
- The choice of linear range critically affects SLP outcomes, highlighting the need for standardized methods.
Conclusions:
- Statistical criteria are essential for accurate and reproducible SLP determination in hyperthermia applications.
- The Peak Analysis Method (PAM) offers a reliable alternative to traditional methods when implemented with objective range selection.
- An open-access website (SLPcalculator.com) is now available for systematic and user-friendly SLP estimation using PAM and F-test.
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