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Updated: Feb 11, 2026

Molten-Salt Synthesis of Complex Metal Oxide Nanoparticles
Published on: October 27, 2018
N-Arylation of isatins with diaryliodonium salts under transition metal-free conditions
Polina V Zaikina1, Dmitry I Bugaenko1, Alexander V Karchava1
1Department of Chemistry, Moscow State University, 1/3 Leninskie Gory, Moscow, 119991, Russia. bugaenko@org.chem.msu.ru.
Abstract:
Substituted isatins exhibit a variety of biological activities and serve as versatile intermediates for accessing diverse medicine-relevant compounds. While N-alkylated isatins are easily obtained through a deprotonation-alkylation sequence, the synthesis of their N-arylated counterparts remains challenging. Herein, we report a new improved method for the N-arylation of isatins with diaryliodonium salts under transition-metal-free conditions. The protocol is scalable, compatible with the most widespread functional groups and applicable to sterically hindered molecules, and may be useful for utilization in medicinal chemistry.
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