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HBV status modulates transaminase decrease after switching from tenofovir disoproxil fumarate to tenofovir

Giuseppe Lapadula1,2, Alessandro Soria2, Laura Antolini3

  • 1School of Medicine, University of Milano-Bicocca, Milan, Italy.

The Journal of Antimicrobial Chemotherapy
|February 10, 2026
PubMed
Summary

Switching HIV patients from tenofovir disoproxil fumarate (TDF) to tenofovir alafenamide (TAF) significantly reduces liver enzymes, particularly in those with chronic hepatitis B. TAF offers a favorable option, but metabolic changes require monitoring.

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