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Exosomes: From Non-Invasive Detection to Engineered Targeted Therapy.

Mingming Sun1, Hang Hu1, Yi Gong1,2

  • 1School of Life Sciences, Nanchang University, Nanchang, China.

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
|February 10, 2026
PubMed
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Exosomes, tiny nanovesicles in bodily fluids, show promise for non-invasive disease diagnosis and targeted drug delivery. Advances in exosome engineering enhance their potential as diagnostic biomarkers and therapeutic carriers.

Keywords:
engineering strategiesexosomenon‐invasive diagnosis

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Area of Science:

  • Biotechnology
  • Nanomedicine
  • Molecular Biology

Background:

  • Exosomes are natural nanovesicles involved in intercellular communication.
  • They possess low immunogenicity and high biocompatibility, enabling passage through biological barriers.

Purpose of the Study:

  • To review exosome applications in disease diagnosis and treatment.
  • To discuss advancements in exosome engineering for targeted delivery and immunomodulation.

Main Methods:

  • Literature review of exosome applications.
  • Analysis of exosome engineering techniques (genetic and chemical modifications).

Main Results:

  • Exosomes serve as biomarkers for non-invasive disease detection.
  • Engineered exosomes function as effective drug delivery vehicles and in vaccine development.

Conclusions:

  • Exosomes hold significant potential for transforming non-invasive diagnostics.
  • They are promising as sophisticated carriers for advanced therapeutic strategies.