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Related Experiment Video

Updated: Feb 11, 2026

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Programmable Biohybrid Probiotics with Long-Term Storage Stability for Enhanced Intestinal Microbiota Regulation and

Jiani Jiang1, Jiangyan Dong1, Zhouping Tian1

  • 1Guangdong Engineering Research Center of Low-Carbon Synthetic Biotechnology, State Key Laboratory of Pulp and Paper Engineering, School of Biology and Biological Engineering, South China University of Technology, Guangzhou, P. R. China.

Small (Weinheim an Der Bergstrasse, Germany)
|February 10, 2026
PubMed
Summary

A novel biohybrid probiotic system significantly improves storage stability and gut survival for treating ulcerative colitis (UC). This engineered therapeutic targets inflammation and microbial imbalance, showing promise for complex inflammatory diseases.

Keywords:
anaerobic probioticsgut microbiotapolyphenolsilicaulcerative colitis

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Area of Science:

  • Biomaterials Science
  • Microbiology
  • Gastroenterology

Background:

  • Ulcerative colitis (UC) presents limited treatment options and frequent relapses.
  • Live bacterial therapeutics (LBTs) show potential for UC but face challenges in stability and efficacy.
  • Existing LBTs struggle with storage, survival in the gut, and targeted therapeutic action.

Purpose of the Study:

  • To develop a robust, multi-functional biohybrid probiotic system for enhanced UC treatment.
  • To overcome the limitations of current LBTs regarding stability, survivability, and therapeutic delivery.
  • To create a programmable, pathology-responsive platform for complex inflammatory diseases.

Main Methods:

  • Engineered a biohybrid probiotic system (Bif@FCSM(A)) using a metal-polyphenol network, silica shell, and MIL-101(Fe) nanocomponents.
  • Incorporated Bifidobacterium longum and 5-aminosalicylic acid within the hierarchical structure.
  • Utilized transferrin-mediated Fe3+ chelation for inflammation-responsive drug release and bacterial activation.
  • Evaluated the system in a dextran sulfate sodium-induced murine UC model.

Main Results:

  • Achieved a 41-fold increase in aerobic storage stability and an 871-fold enhancement in gastric survivability.
  • Demonstrated spatiotemporally controlled bacterial activation and drug release in inflamed colonic tissue.
  • Significantly alleviated UC disease severity, suppressed pro-inflammatory cytokines, and restored immune homeostasis in a mouse model.
  • Enriched beneficial short-chain fatty acid-producing gut bacteria.

Conclusions:

  • The developed biohybrid probiotic platform offers enhanced stability and targeted delivery for UC treatment.
  • This programmable, pathology-responsive system demonstrates significant therapeutic potential for inflammatory bowel diseases.
  • The strategy provides a foundation for engineering advanced probiotics for complex diseases.