Related Experiment Video
Updated: Feb 11, 2026
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Removal of Trace Elements by Cupric Oxide Nanoparticles from Uranium In Situ Recovery Bleed Water and Its Effect on Cell Viability
Published on: June 21, 2015
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Uranium Chelation by Pyrazine-2-amidoxime: Speciation, Decorporation, and Computational Studies
Ashutosh Srivastava1, Manjoor Ali2, Naman K Bharti3,4
1Radiochemistry Division, Bhabha Atomic Research Centre, Mumbai 400085, India.
Inorganic Chemistry
|February 10, 2026
Summary
Pyrazine-2-amidoxime (PAM) effectively chelates uranium, forming stable complexes. This novel chelator shows promise for uranium decorporation, safely removing it from blood and cells.
Area of Science:
- Environmental Science
- Toxicology
- Medicinal Chemistry
Background:
- Uranium's chemo-radiotoxicity necessitates effective confinement and decorporation strategies.
- Chelation therapy using multidentate ligands is a key approach for uranium removal.
Purpose of the Study:
- To investigate uranium complexation with pyrazine-2-amidoxime (PAM) for the first time.
- To evaluate PAM's efficacy in uranium decorporation from biological systems.
Main Methods:
- Potentiometric and spectrophotometric titrations.
- Electrospray ionization mass spectrometry (ESI-MS).
- Density functional theory (DFT) calculations and ex vivo studies with human erythrocytes, proteins, and blood plasma.
Main Results:
- PAM forms stable 1:1 and 1:2 complexes with uranyl ions (UO22+).
- High stability constants (log β) were determined for PAM-uranyl complexes.
- PAM demonstrated significant uranium decorporation (25-40%) from human erythrocytes and reduced uranium (10-20%) from proteins and blood plasma.
- PAM was confirmed to be cytocompatible.
Conclusions:
- Pyrazine-2-amidoxime is a highly effective bidentate chelator for uranyl ions.
- PAM shows significant potential as a therapeutic agent for uranium decorporation due to its efficacy and cytocompatibility.
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