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Cross-Modal Multivariate Pattern Analysis
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Prediction and Prevention of Delayed Post-polypectomy-induced Ulcer Hemorrhage Based Upon an Anatomic Study and
Dennis M Jensen1,2,3, Jeffrey Gornbein4, Phillip Fejleh5
1David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. djensen@mednet.ucla.edu.
Digestive Diseases and Sciences
|February 10, 2026
Summary
Doppler endoscopic probe (DEP) detection of polyp artery blood flow is a new risk factor for delayed post-polypectomy-induced ulcer hemorrhage (DPPIUH). DEP-guided treatment effectively prevents DPPIUH, improving patient outcomes.
Area of Science:
- Gastroenterology
- Endoscopic procedures
- Surgical pathology
Background:
- Delayed post-polypectomy-induced ulcer hemorrhage (DPPIUH) poses a significant clinical challenge.
- Improved methods for predicting and preventing DPPIUH are crucial for patient safety.
Purpose of the Study:
- To establish the correlation between Doppler endoscopic probe (DEP) detection of pulsatile blood flow and polyp artery size.
- To identify and report risk factors for DPPIUH and evaluate preventative strategies.
Main Methods:
- A cohort study of 96 high-risk patients with large colon polyps (10-40 mm).
- Histological analysis of polyp resection margins to determine artery size.
- Comparison of DEP-positive and DEP-negative patients, with and without hemoclip (HC) intervention.
- Multivariable logistic analysis and classification tree modeling to assess 16 potential risk factors.
Main Results:
- DEP positivity strongly predicted medium or large polyp arteries (OR 23.4).
- Key risk factors for DPPIUH included DEP positivity, larger polyp arteries, right colon location, and prior empiric hemoclip closure.
- DEP-guided treatment was associated with the absence of DPPIUH.
Conclusions:
- DEP positivity and polyp artery size are significant predictors of DPPIUH.
- Right colon location and empiric hemoclip use are additional risk factors.
- DEP-guided intervention successfully prevented DPPIUH.
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