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Related Experiment Video

Updated: Feb 12, 2026

Visualizing Lymph Node Structure and Cellular Localization using Ex-Vivo Confocal Microscopy
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SCOUT Localization at Time of Lymph Node Biopsy.

Meng Hao1, Steven P Poplack1, Jean Bao2

  • 1Department of Radiology, Stanford University, Stanford, CA, USA.

Journal of Breast Imaging
|February 10, 2026
PubMed
Summary

SCOUT radar localization placement during axillary lymph node biopsy aids in identifying the biopsied node. This technique shows particular benefit for patients undergoing neoadjuvant treatment and women under 50.

Keywords:
SCOUTaxillalocalizationlymph node biopsysentinel node

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Area of Science:

  • Oncology
  • Surgical Oncology
  • Radiology

Background:

  • Axillary lymph node biopsy is crucial for staging breast cancer.
  • Accurate localization of biopsied lymph nodes is essential for effective treatment.
  • Neoadjuvant treatment can alter lymph node characteristics, complicating localization.

Purpose of the Study:

  • To evaluate the effectiveness of SCOUT radar localization placement during axillary lymph node core-needle biopsy.
  • To determine the utilization rate and impact of SCOUT in guiding axillary surgery.

Main Methods:

  • Retrospective analysis of 127 patients undergoing SCOUT placement during axillary lymph node core-needle biopsy (January 2018 - September 2023).
  • SCOUT utilization defined by detection and removal during axillary dissection.
  • Statistical analysis using Fisher's exact test and Wilcoxon rank-sum test.

Main Results:

  • SCOUT was placed in 127 patients; 70% were utilized in subsequent axillary surgery.
  • The SCOUT-localized node was not identified by blue dye or radiotracer in 28% of malignant cases, especially post-neoadjuvant treatment.
  • Utilization was significantly higher in patients under 50 years old (87%).

Conclusions:

  • SCOUT placement facilitates accurate detection of the biopsied lymph node.
  • The technology is particularly beneficial in patients who received neoadjuvant treatment.
  • SCOUT shows promise for improving lymph node localization in younger women (<50 years old).