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Over 40 Years of Experience With Aortic Valve Surgery in the Paediatric Population-What Is the Current Best Strategy?
Viktoria Weixler1, Amanda Greenwell1, Alison Howell2
1Division of Cardiovascular Surgery, The Labatt Family Heart Center, The Hospital of Sick Children, Toronto, ON M5G 1X8, Canada.
Insights
Congenital aortic valve disease in children has limited options. Surgical valvuloplasty (SAV) leads to more reoperations, while the Ross procedure is safe and durable, preserving native valves in suitable cases.
Area of Science:
- Pediatric Cardiology
- Congenital Heart Disease
- Cardiac Surgery
Background:
- Congenital aortic valve (AoV) disease presents limited therapeutic options for pediatric patients.
- Evaluating initial surgical strategies is crucial for long-term outcomes in growing children.
Purpose of the Study:
- To compare the effectiveness of different initial surgical strategies for congenital aortic valve disease in children.
- To determine the optimal treatment strategy balancing survival and reoperation rates.
Main Methods:
- A retrospective analysis of pediatric patients undergoing aortic valve surgery (SAV, AVR, Ross procedure) from 1976 to 2024.
- Evaluation of factors like prior balloon valvuloplasty (BAV), valve morphology, and disease type (stenosis/regurgitation).
- Assessment of survival rates and incidence of reoperation, moderate aortic valve insufficiency, and stenosis.
Main Results:
- Excellent 10- and 20-year survival rates (90.4% and 87.1%) were observed across all initial surgical groups.
- Surgical valvuloplasty (SAV) had a significantly higher incidence of reoperations at 20 years (78.4%) compared to aortic valve replacement (AVR) (24.6%) and the Ross procedure (15%).
- Favorable aortic valve anatomy and stenosis were associated with native valve survival at 20 years.
Conclusions:
- All initial surgical approaches for congenital aortic valve disease offer excellent short- and long-term survival.
- The Ross procedure is identified as a safe and durable option with a lower reoperation rate.
- Early surgical valvuloplasty can preserve the native valve in cases with favorable anatomy.
Objectives:
Congenital aortic valve (AoV) disease has limited treatment options in growing children. Different initial strategies, AoV repair/surgical valvuloplasty (SAV), AoV replacement (AVR), and Ross procedure were compared to elucidate the current best strategy.
Methods:
All paediatric patients undergoing different initial AoV surgeries from 1976 to 2024 were included. Factors including prior balloon dilation (balloon valvuloplasty [BAV]), valve morphology, and initial disease (stenosis/regurgitation/mixed) were analysed. Survival and incidence of AoV reoperation/≥moderate AoV insufficiency/stenosis were evaluated.
Results:
A total of 323 patients underwent 142 SAV/33 AVR/137 Ross at median age/weight of 5.7 years [interquartile range, 0.5-12.6]/19.9 kg [6.9-48.8]. Surgical valvuloplasty group was the youngest (P < .01). Thirty-day mortality was 2.5% (8/323) without group differences (P = .15). Median follow-up was 9.6 years [2.7-17.8] with 10-/20-year survival rates of 90.4% [86.1-93.4]/87.1% [81.4-91.1] without group differences. Twenty-year cumulative incidences of AoV reoperations were higher after SAV: 78.4% [70.8-86.9] vs 24.6% [11.7-51.7] after AVR and 15% [6.8-33.1] after Ross, P < .01. Survivors with their native AoV at 20 years (n = 48, 14.8%) were younger at initial surgery (P < .01), had predominantly AoV stenosis (91.7%), and had fewer BAVs (P < .01). Cox regression demonstrated 7.8-fold higher mortality hazard after AVR (P < .01) and a lower reoperation hazard after AVR and Ross (HR 0.1 [95% CI, 0.1-0.5], P < .01 and HR 0.1 [95% CI, 0.1-0.3], P < .01) compared to SAV.
Conclusions:
All initial AoV surgeries brought excellent early/long-term survival. Aortic valve reoperations occur most frequently after SAV. In case of favourable AoV anatomy, early SAV can preserve the native valve. Ross procedure identified as safe and durable.
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