Related Experiment Video
Updated: Feb 12, 2026

Author Spotlight: Overcoming Anti-VEGF Resistance Through Advanced Vascular Morphology Assessment in Choroidal Neovascularization
Published on: August 11, 2023
Bilateral Macular Neovascularization Secondary to Sepsis from a Shunt Infection
Takuya Shunto1, Chikako Hara1, Tatsuto Inoue2
1Department of Ophthalmology, Osaka University Graduate School of Medicine. Suita, Japan.
Purpose:
To report a case of bilateral macular neovascularization (MNV) secondary to septic embolism from a shunt infection.
Methods:
Observational case report.
Results:
A 57-year-old female on maintenance hemodialysis experienced cardiac arrest due to sepsis and was resuscitated with an automated external defibrillator. Blood cultures grew methicillin-sensitive Staphylococcus aureus (MSSA). Echocardiography showed no evidence of infective endocarditis (IE); a pseudoaneurysm of the shunt vessel was identified as the likely source of infection. Chest computed tomography revealed a septic pulmonary embolus. Three weeks later, the patient developed metamorphopsia in the right eye. Visual acuity at presentation was 20/25 (right) and 20/20 (left). Ophthalmological evaluation, including optical coherence tomography (OCT) and OCT angiography, confirmed bilateral type 2 MNV. She received intravitreal aflibercept injections in both eyes, which reduced MNV activity and improved symptoms. No recurrence occurred over one year of follow-up.
Conclusion:
Bilateral MNV can develop in patients with sepsis due to shunt infection without evidence of IE. This case underscores the need to consider MNV as a potential complication not only in IE-related sepsis but also in sepsis from other sources, such as shunt infections.
Related Concept Videos
Shunt Admittances
To model this effect, the method of images is employed. This method involves replacing the Earth with an image conductor that mirrors the original...
Secondary Active Transport
Secondary Active Transport
Secondary Healthcare System
Primary and Secondary Growth in Roots and Shoots
Secondary Distribution
In residential areas, 120/240 V single-phase, three-wire service is commonly used for lighting, outlets, and large appliances. Urban areas with high-density loads...

