Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Olfaction01:25

Olfaction

48.9K
The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
48.9K
Breathing01:05

Breathing

64.7K
The process of breathing, inhaling and exhaling, involves the coordinated movement of the chest wall, the lungs, and the muscles that move them. Two muscle groups with important roles in breathing are the diaphragm, located directly below the lungs, and the intercostal muscles, which lie between the ribs. When the diaphragm contracts, it moves downward, increasing the volume of the thoracic cavity and creating more room for the lungs to expand. When the intercostal muscles contract, the ribs...
64.7K
What is a Hypothesis?01:14

What is a Hypothesis?

15.2K
A hypothesis can be a simple sentence or statement about a property or any phenomenon observed or predicted for a population. It is usually a claim about a  property of the population. It can be stated for any field observations or experiments. A hypothesis statement cannot be said to be right or wrong as it is merely a statement. It needs to be tested through an elaborate data collection process and an appropriate statistical test. A hypothesis should be a general but not a vague...
15.2K
Types of Hypothesis Testing01:11

Types of Hypothesis Testing

28.1K
There are three types of hypothesis tests: right-tailed, left-tailed, and two-tailed.
When the null and alternative hypotheses are stated, it is observed that the null hypothesis is a neutral statement against which the alternative hypothesis is tested. The alternative hypothesis is a claim that instead has a certain direction. If the null hypothesis claims that p = 0.5, the alternative hypothesis would be an opposing statement to this and can be put either p > 0.5, p < 0.5, or p...
28.1K
Errors In Hypothesis Tests01:14

Errors In Hypothesis Tests

6.1K
When performing a hypothesis test, there are four possible outcomes depending on the actual truth (or falseness) of the null hypothesis and the decision to reject or not.
6.1K
Hypothesis Test for Test of Independence01:16

Hypothesis Test for Test of Independence

8.2K
The test of independence is a chi-square-based test used to determine whether two variables or factors are independent or dependent. This hypothesis test is used to examine the independence of the variables. One can construct two qualitative survey questions or experiments based on the variables in a contingency table. The goal is to see if the two variables are unrelated (independent) or related (dependent). The null and alternative hypotheses for this test are:
H0: The two variables (factors)...
8.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Canine Olfaction Combined With Bayesian Modeling for Multicancer Detection From Breath Samples: A Phase II Study in India.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2026
Same author

Optimizing electrode placement and information capacity for local field potentials in cortex.

NeuroImage·2026
Same author

Optimizing electrode placement and information capacity for local field potentials in cortex.

bioRxiv : the preprint server for biology·2025
Same author

Simultaneous detection and differentiation of dengue and chikungunya viruses for commercial utility.

Virusdisease·2023
Same author

Localized spatial distributions of disease phases yield long-term persistence of infection.

Scientific reports·2020
Same author

Emergence of extreme events in networks of parametrically coupled chaotic populations.

Chaos (Woodbury, N.Y.)·2019

Related Experiment Video

Updated: Feb 12, 2026

Rapid Homogeneous Detection of Biological Assays Using Magnetic Modulation Biosensing System
06:58

Rapid Homogeneous Detection of Biological Assays Using Magnetic Modulation Biosensing System

Published on: June 13, 2010

10.1K

Digitized canine olfaction and multimodal biosensing for breath-based multi-cancer detection: a hypothesis-driven

Minal Dakhave1, Itamar Bitan1,2, Promit Moitra1

  • 1Dognosis India Pvt. Ltd, Bangalore, Karnataka, India.

Journal of Breath Research
|February 10, 2026
PubMed
Summary

Trained dogs detect cancer early using scent and brain signals. This novel bio-digital platform offers a scalable, low-cost Multi-Cancer Early Detection (MCED) solution, especially for low-resource areas.

Keywords:
EEGbreath analysiscanine olfactionearly cancer detectionmachine learningvolatile organic compounds

More Related Videos

Detection of a CDH1 Rare Transcript Variant in Fresh-frozen Gastric Cancer Tissues by Chip-based Digital PCR
09:16

Detection of a CDH1 Rare Transcript Variant in Fresh-frozen Gastric Cancer Tissues by Chip-based Digital PCR

Published on: February 5, 2018

6.6K
Acquisition of High-Quality Digital Video of Drosophila Larval and Adult Behaviors from a Lateral Perspective
07:00

Acquisition of High-Quality Digital Video of Drosophila Larval and Adult Behaviors from a Lateral Perspective

Published on: October 4, 2014

9.2K

Related Experiment Videos

Last Updated: Feb 12, 2026

Rapid Homogeneous Detection of Biological Assays Using Magnetic Modulation Biosensing System
06:58

Rapid Homogeneous Detection of Biological Assays Using Magnetic Modulation Biosensing System

Published on: June 13, 2010

10.1K
Detection of a CDH1 Rare Transcript Variant in Fresh-frozen Gastric Cancer Tissues by Chip-based Digital PCR
09:16

Detection of a CDH1 Rare Transcript Variant in Fresh-frozen Gastric Cancer Tissues by Chip-based Digital PCR

Published on: February 5, 2018

6.6K
Acquisition of High-Quality Digital Video of Drosophila Larval and Adult Behaviors from a Lateral Perspective
07:00

Acquisition of High-Quality Digital Video of Drosophila Larval and Adult Behaviors from a Lateral Perspective

Published on: October 4, 2014

9.2K

Area of Science:

  • Biotechnology
  • Computational Biology
  • Veterinary Medicine

Background:

  • Current Multi-Cancer Early Detection (MCED) methods face challenges in cost, accessibility, and sensitivity.
  • Breath analysis of volatile organic compounds (VOCs) presents a promising non-invasive screening approach.
  • Trained dogs show high olfactory sensitivity for disease detection, but lack standardization.

Purpose of the Study:

  • To propose a novel canine olfaction-based MCED platform integrating multiple biomarkers.
  • To leverage machine learning for analyzing dog's EEG, behavioral, and physiological data.
  • To establish a pathway for reproducible, portable, and scalable cancer detection.

Main Methods:

  • Utilizing electroencephalography (EEG) signals from trained dogs to analyze olfactory recognition.
  • Combining EEG data with behavioral (vision tracking) and physiological (respiration, heart rate) biomarkers.
  • Developing a machine learning model to integrate multimodal data and generate a cancer risk score.

Main Results:

  • The proposed Dognosis platform integrates bio-digital data for cancer risk assessment.
  • Preliminary validation strategies and a phased experimental roadmap are outlined.
  • The framework aims for reproducible, portable, scalable, and low-cost cancer detection.

Conclusions:

  • The bio-digital canine olfaction platform offers a novel approach to MCED.
  • This system has potential for deployment in low-resource settings and broader disease detection.
  • Standardization and reproducibility are key advancements for canine scent detection in diagnostics.