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Antimuscarinic Toxicity Safely Managed with High-Dose Transdermal Rivastigmine: A Case Report
C James Watson1, Emilie M Burrill2,3, William S Jaffee1,4
1Tufts University School of Medicine, Boston, Massachusetts.
High-dose transdermal rivastigmine effectively managed antimuscarinic toxicity symptoms in a patient, offering a potential alternative during physostigmine shortages. This approach demonstrated sustained symptom control without adverse effects.
Area of Science:
- Pharmacology
- Toxicology
- Neurology
Background:
- Antimuscarinic toxicity presents risks like delirium and behavioral changes.
- Physostigmine shortages necessitate alternative treatments for antimuscarinic toxicity.
- Standard dosing of transdermal rivastigmine shows equivocal efficacy for symptom control.
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