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Updated: Feb 12, 2026

Author Spotlight: Insights and Innovations in Gene Expression Manipulation Techniques for Choroid Plexus Research
Published on: June 16, 2023
Choroid plexus enlargement associates with serum neurofilament and predicts relapse-free progression in multiple
Vinzenz Fleischer1, Muriel Schraad1, Gabriel Gonzalez-Escamilla1
1Department of Neurology, Research Center for Immunotherapy (FZI) and Focus Program Translational Neuroscience (FTN), Rhine Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, Germany.
Abstract:
The choroid plexus (CP), a key regulator of cerebrospinal fluid production and immune cell trafficking, is increasingly recognized as a potential magnetic resonance imaging (MRI) biomarker in multiple sclerosis (MS). Serum neurofilament light chain (sNfL) serves as a sensitive blood-based indicator of neuroaxonal injury. We investigate the prognostic value of CP volume and its longitudinal change for neurodegeneration, defined by sNfL levels and disability progression. In a prospective, multicenter, longitudinal study, 891 people with MS undergo high-resolution 3T MRI, sNfL measurement, and clinical assessment over 6 years; 434 meet criteria for inclusion. CP volume correlates with sNfL after adjustment for demographic, clinical, treatment, and imaging variables. In a 2-year MRI subcohort (n = 209), CP enlargement likewise associates with sNfL. High CP volume confers a 1.8-fold increased risk of disability worsening and a 2.7-fold increased risk of progression independent of relapse activity. These findings identify CP imaging as a promising non-invasive biomarker of neuroaxonal loss and relapse-free progression.
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