Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Notch Signaling Pathway03:14

Notch Signaling Pathway

6.6K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
6.6K
Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

10.1K
The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
10.1K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

7.4K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
7.4K
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

8.5K
Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
8.5K
Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

10.7K
The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
10.7K
NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

10.1K
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
10.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Single-cell heterogeneity in ribosome levels and protein synthesis during nutrient starvation is driven by cAMP signaling.

Science advances·2026
Same author

<i>Mycobacterium tuberculosis</i> does not inhibit NLRP1 and pyrin inflammasomes in human macrophages.

Microbiology spectrum·2026
Same author

Characterization of programmed cell death pathways activated in Mycobacterium tuberculosis-infected human macrophages.

Cell death discovery·2026
Same author

Protein kinase F regulates the virulence of <i>Mycobacterium tuberculosis</i>.

bioRxiv : the preprint server for biology·2026
Same author

NLRP11 is required for canonical NLRP3 and non-canonical inflammasome activation during human macrophage infection with mycobacteria.

mBio·2025
Same author

NLRP11 is required for canonical NLRP3 and non-canonical inflammasome activation during human macrophage infection with mycobacteria.

bioRxiv : the preprint server for biology·2025

Related Experiment Video

Updated: Feb 12, 2026

Imaging Mycobacterium tuberculosis in Mice with Reporter Enzyme Fluorescence
10:06

Imaging Mycobacterium tuberculosis in Mice with Reporter Enzyme Fluorescence

Published on: February 26, 2018

7.8K

Host Cell Death Signaling Pathways Manipulated by Mycobacterium tuberculosis.

Guanchao Ding1, Volker Briken2

  • 1Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland 20742, USA.

Cold Spring Harbor Perspectives in Medicine
|February 10, 2026
PubMed
Summary

Mycobacterium tuberculosis (Mtb) triggers necrotic macrophage death, hindering lung function in tuberculosis. Mtb manipulates programmed necrosis (necroptosis, pyroptosis, ferroptosis) and inhibits apoptosis, impacting disease progression.

More Related Videos

Separation and Fractionation of Cell Wall and Cell Membrane Proteins from Mycobacterium tuberculosis for Downstream Protein Analysis
06:14

Separation and Fractionation of Cell Wall and Cell Membrane Proteins from Mycobacterium tuberculosis for Downstream Protein Analysis

Published on: September 26, 2025

691
Growth of Mycobacterium tuberculosis Biofilms
09:03

Growth of Mycobacterium tuberculosis Biofilms

Published on: February 15, 2012

24.5K

Related Experiment Videos

Last Updated: Feb 12, 2026

Imaging Mycobacterium tuberculosis in Mice with Reporter Enzyme Fluorescence
10:06

Imaging Mycobacterium tuberculosis in Mice with Reporter Enzyme Fluorescence

Published on: February 26, 2018

7.8K
Separation and Fractionation of Cell Wall and Cell Membrane Proteins from Mycobacterium tuberculosis for Downstream Protein Analysis
06:14

Separation and Fractionation of Cell Wall and Cell Membrane Proteins from Mycobacterium tuberculosis for Downstream Protein Analysis

Published on: September 26, 2025

691
Growth of Mycobacterium tuberculosis Biofilms
09:03

Growth of Mycobacterium tuberculosis Biofilms

Published on: February 15, 2012

24.5K

Area of Science:

  • Immunology
  • Cell Biology
  • Microbiology

Background:

  • Tuberculosis (TB) pathogenesis involves Mycobacterium tuberculosis (Mtb) inducing host cell death.
  • Mtb infection leads to necrotic macrophage death, contributing to lung tissue damage and dysfunction.
  • Multiple programmed cell death pathways, including necroptosis, pyroptosis, and ferroptosis, are implicated in Mtb infection.

Purpose of the Study:

  • To provide an overview of programmed cell death pathways activated by Mtb infection.
  • To discuss the mechanisms by which Mtb manipulates these cell death pathways.
  • To compare Mtb's effects on macrophage cell death across different species (mouse, human, zebrafish).

Main Methods:

  • Literature review of programmed cell death pathways in Mtb infection.
  • Analysis of Mtb's manipulation of necroptosis, pyroptosis, and ferroptosis.
  • Comparative analysis of Mtb-induced cell death in macrophages from various model organisms.

Main Results:

  • Mtb induces diverse forms of programmed necrosis in macrophages.
  • Mtb actively inhibits apoptosis, a host-protective cell death mechanism.
  • Significant variations exist in Mtb's modulation of cell death pathways across different host macrophage types.

Conclusions:

  • Understanding Mtb's intricate manipulation of host cell death is crucial for TB pathogenesis.
  • Targeting Mtb-induced necrosis or apoptosis inhibition presents potential therapeutic strategies.
  • Species-specific differences in macrophage responses to Mtb highlight the complexity of TB research.