Related Experiment Video
Updated: Feb 12, 2026
09:29
Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies
Published on: September 30, 2016
14.5K
Thrombocytopenia and Bleeding in Patients With Oncologic Emergencies Following Cancer Therapy
Le Tian1, Jia-Xin Huang1, Xi Zhang1
1Department of Comprehensive Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Cancer Medicine
|February 10, 2026
Summary
Cancer therapy-induced thrombocytopenia (CTIT) affects 13.5% of emergency oncology patients. Fever and pleural effusion are key risk factors for CTIT-related bleeding, necessitating increased clinical vigilance.
Area of Science:
- Oncology
- Hematology
- Emergency Medicine
Background:
- Cancer therapy-induced thrombocytopenia (CTIT) is a significant complication.
- Limited data exists on CTIT-related hemorrhage risk factors in emergency oncology patients, particularly from China.
Purpose of the Study:
- To investigate the incidence and risk factors for CTIT and associated organ hemorrhage in Chinese emergency oncology patients.
- To identify predictors of CTIT-related bleeding.
Main Methods:
- Retrospective study of 8590 emergency oncology visits.
- Analysis of clinical features and outcomes for 1164 patients with CTIT.
- Identification of independent risk factors for CTIT and hemorrhage.
Main Results:
- CTIT occurred in 13.5% of patients (1164/8590).
- Organ hemorrhage was observed in 5.24% of CTIT cases (61/1164).
- Independent risk factors for CTIT deterioration included ECOG score 2-4, stage IV malignancy, organ bleeding, anemia, and fever.
- Independent risk factors for CTIT-related bleeding were fever (OR=4.886) and pleural effusion (OR=4.812).
- Lung cancer was the most common malignancy (41%) among bleeding cases.
Conclusions:
- Malignancies leading to reduced platelet counts, coupled with specific risk factors, demand heightened clinical attention for hemorrhage.
- Fever and pleural effusion are critical indicators for predicting bleeding risk in CTIT patients.
Related Concept Videos
02:49Cancer Therapies
10.2K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
10.2K
02:57Targeted Cancer Therapies
9.0K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
9.0K
01:27Emerging Adulthood
725
Jeffrey Arnett's concept of emerging adulthood offers a framework to understand the unique developmental stage between adolescence and full-fledged adulthood, generally from ages 18 to 25. This period is marked by extensive exploration and shifts in identity, relationships, and career choices, a process known in psychology as role experimentation. Emerging adulthood reflects the evolving cultural expectations surrounding adulthood and the dynamic process of personal transformation during...
725
01:22Bleeding in Fresh Concrete
616
Bleeding in fresh concrete occurs when water from the mix rises to the surface. This happens because the mix's solid components fail to retain all the water as they settle, leading to separation where water collects at the top. The severity of bleeding can be measured by assessing the total settlement or by noting the decrease in height per unit height of concrete.
Bleeding can cause several issues in the concrete structure. Sometimes, the rising water gets trapped beneath large aggregate...
Bleeding can cause several issues in the concrete structure. Sometimes, the rising water gets trapped beneath large aggregate...
616
01:30Introduction Cardiac Emergencies
379
Cardiac emergencies are critical situations involving the heart that require immediate medical intervention to prevent severe complications or death. These emergencies often arise from underlying heart conditions that impair the heart's ability to function correctly.Types of Cardiac EmergenciesThe most common types of cardiac emergencies include Acute Coronary Syndrome (ACS), myocardial infarction (MI), cardiac arrest, and heart failure.Acute Coronary Syndrome (ACS)Acute Coronary Syndrome (ACS)...
379
00:59Gene Therapy
27.7K
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.7K