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Updated: Feb 12, 2026

Mouse Model of Pressure Ulcers After Spinal Cord Injury
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Pressure Injuries and Skin Failure: The Search for Clarity.

Jeffrey M Levine1,2

  • 1Brookdale Department of Geriatrics & Palliative Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

International Wound Journal
|February 11, 2026
PubMed
Summary
This summary is machine-generated.

Skin failure, a complex condition, lacks consistent definitions and diagnostic criteria, complicating patient care and quality reporting. A unified definition is needed to improve assessment and outcomes for vulnerable patients.

Keywords:
pressure injuriesquality measurement healthcare qualityskin failureterminal ulcerwound care

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Area of Science:

  • Medical Science
  • Wound Care
  • Healthcare Management

Background:

  • Skin failure is increasingly recognized but lacks consistent definitions and diagnostic criteria.
  • This ambiguity hinders accurate bedside assessment, documentation, and quality reporting in healthcare settings.
  • Historically, pressure injuries were considered preventable, but evidence suggests some develop despite optimal care, especially in patients with multimorbidity.

Purpose of the Study:

  • To review the historical development of skin failure and its connection to pressure injury theories.
  • To analyze the proliferation of definitions and overlapping terms causing documentation and classification issues.
  • To advocate for a unified definition of skin failure for improved diagnosis and care quality evaluation.

Main Methods:

  • Historical review of skin failure and pressure injury theories from the 19th century.
  • Analysis of contemporary definitions, overlapping terms, and classification systems.
  • Identification of key factors contributing to skin failure, including systemic vulnerabilities.

Main Results:

  • Inconsistent definitions and diagnostic criteria for skin failure complicate clinical practice.
  • Skin failure results from the interplay of tissue deformation and systemic vulnerabilities (e.g., hypoperfusion, inflammation, edema).
  • Existing terminology and classification systems lack clarity and interdisciplinary consensus.

Conclusions:

  • A unified, practical definition of skin failure is urgently needed across all healthcare settings and patient populations.
  • Standardized terminology and interdisciplinary consensus are crucial for accurate diagnosis and equitable care evaluation.
  • Development of predictive tools integrating physiologic data and patient-centered outcomes is recommended.