Related Experiment Video
Updated: Feb 12, 2026

A Micropatterning Assay for Measuring Cell Chirality
Published on: March 11, 2022
Cu-Catalyzed Atroposelective Protoboration of Allenes to Access Stereodefined Tetrasubstituted Axially Chiral
Baoli Li1, Zhan Huang1, Shichao Hong2
1Department of Applied Chemistry, Anhui Province Engineering Laboratory for Green Pesticide Development and Application, and Anhui Province Key Laboratory of Crop Integrated Pest Management, Anhui Agricultural University, Hefei 230036, China.
Abstract:
Alkenylboronates represent a cornerstone functional group in modern organic synthesis owing to their versatile reactivity in Suzuki-Miyaura cross-coupling reactions and other key transformations. However, catalytic asymmetric methods for producing stereodefined tetrasubstituted axially chiral alkenylboronates remain underdeveloped. Here, we report a copper-catalyzed atroposelective protoboration of allenes, providing a facile strategy to access tetrasubstituted axially chiral Z-alkenylboronates with excellent regio- and atroposelectivities. The enantiomerically enriched axially chiral alkenylboronates could be further transformed into diverse stereodefined tetrasubstituted axially chiral olefins via the cross-coupling reaction of the C-B bond. This methodology also provides a new avenue to construct C-C or C-N axially chiral alkene-phosphine frameworks.
Related Concept Videos
Chirality
Chiral objects exhibit a sense of handedness when they interact with another chiral object. For example, our left foot can only fit in the left shoe and not in the right shoe. Achiral objects — objects that have...
Chirality in Nature
Axial and Appendicular Muscles
Axial Muscles
Axial muscles, situated along the body's midline, are intricately connected to the axial skeleton, which includes the skull, spine, ribs, and sternum. These muscles facilitate facial expressions and...
Chirality at Nitrogen, Phosphorus, and Sulfur
A consequence of chirality is the need for enantiomeric resolution. While this is theoretically possible for all...
Overview of the Axial Skeleton
The axial skeleton of the...
General Case of Eccentric Axial Loading
Consider a member subjected to equal and opposite forces that are applied along a line that does not coincide with the member's neutral axis. In unsymmetrical...

