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One-Year Outcome of Japanese Patients With Atrial Fibrillation: Insights From APHRS-AF Registry

Kenji Yodogawa1, Yu-Ki Iwasaki1, Yasuo Okumura2

  • 1Department of Cardiovascular Medicine Nippon Medical School Tokyo Japan.

Journal of Arrhythmia
|February 11, 2026
PubMed

Insights

Japanese patients with atrial fibrillation (AF) in the APHRS-AF Registry showed high oral anticoagulant use. One-year outcomes revealed low mortality and stroke incidence, indicating effective management strategies.

Area of Science:

  • Cardiology
  • Epidemiology
  • Clinical Research

Background:

  • The Asia-Pacific Heart Rhythm Society Atrial Fibrillation (APHRS-AF) Registry prospectively collects data on atrial fibrillation (AF) patients across Asian cities.
  • This report focuses on Japanese patients within the registry, detailing their baseline characteristics, treatment patterns, and one-year clinical outcomes.

Purpose of the Study:

  • To analyze the baseline characteristics, therapeutic strategies, and one-year clinical outcomes of Japanese patients diagnosed with atrial fibrillation (AF).
  • To evaluate the effectiveness of oral anticoagulants and catheter ablation in managing AF in this cohort.

Main Methods:

  • Data from 794 Japanese patients with AF, recruited between 2015 and 2017 from 28 centers, were analyzed.
  • One-year follow-up outcomes were assessed for 743 patients, focusing on mortality, stroke, and bleeding events.
  • Baseline characteristics, including comorbidities and risk scores (CHADS2, CHA2DS2-VASc, HAS-BLED), were recorded.

Main Results:

  • The cohort (mean age 65.7 years, 69.0% male) had high rates of hypertension, lipid disorders, heart failure, and diabetes.
  • Oral anticoagulants were used by 81% of patients at baseline (7% VKA, 74% DOAC).
  • One-year outcomes showed a low incidence of all-cause mortality (0.1%) and stroke/thromboembolic events (0.1%), with major bleeding in 0.7% of patients.

Conclusions:

  • Japanese patients in the APHRS-AF Registry exhibit high utilization of oral anticoagulants.
  • The one-year follow-up demonstrates a low mortality rate and a low incidence of stroke/thromboembolic events in this population.
Abstract

Keywords:
AsianJapanatrial fibrillationprospective studiesregistries

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