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Updated: Feb 12, 2026
Tuning the Acidity of Pt/ CNTs Catalysts for Hydrodeoxygenation of Diphenyl Ether
Published on: August 17, 2019
Associations Between Polybrominated Diphenyl Ethers and Biological Aging in NHANES 2005-2010 and 2015-2016
Yan Chen1, Ruilan Gong1, Qianzhu Li2
1Department of Physiology Harbin Medical University Harbin China.
None:
The associations of polybrominated diphenyl ethers (PBDEs) with biological aging are unclear. This study explores the possible relationship between PBDEs and accelerated aging. Cross-sectional data from 6,091 subjects of the National Health and Nutrition Examination Survey (NHANES) 2005-2010 and 2015-2016 are analyzed. Serum PBDE concentrations are quantified via automated liquid-liquid extraction and subsequent sample purification, with seven PBDEs displaying a capture rate higher than 70%, identified as the exposure. Homeostatic dysregulation (HD), Klemera-Doubal method (KDM), phenoAge (PA), and allostatic load (AL) are utilized to assess biological aging. The associations are assessed with weighted multivariate linear regression models, restricted cubic spline (RCS), weighted quantile sum regression, and Quantile G-computation analysis. Regarding individual exposures, significant positive associations of PBDE47, PBDE99, PBDE100, PBDE154, and PBDE85 with HD, KDM residual, and PA residual, and PBDE100 with AL (β > 0, P < 0.050) are detected. The associations are further validated by RCS. Mixed PBDEs show a positive relationship with HD, KDM residual, PA residual, and AL (β > 0, P < 0.050), with PBDE99, PBDE47, and PBDE85 as the most significant contributing PBDEs. Exposure to the PBDE mixture exhibits a positive association with predicted age metrics, highlighting PBDE99, PBDE47, and PBDE85 as the significant chemicals.
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