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Related Experiment Video

Updated: Feb 12, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

B-Cell Lymphoma Following an Indolent Course Over 30 Years with Immunophenotypic Changes at Each Recurrence.

Shintaro Yamanaka¹, Shinji Hasebe¹, Tomomi Fujii²

¹Cancer Center, Ehime University Hospital, Toon city, Japan.

European Journal of Case Reports in Internal Medicine

|February 11, 2026

Summary

Diffuse large B-cell lymphoma (DLBCL) can change its subtype over time, impacting treatment. Repeat biopsies are crucial for accurate diagnosis and personalized therapy in relapsed cases.

Keywords:

ABC type Diffuse large B-cell lymphoma (DLBCL)GCB type gene expression profiling immunophenotype

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Last Updated: Feb 12, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

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Published on: March 30, 2018

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Published on: April 3, 2011

Bioprinting of Hydrogel Tumor Slices as a 3D Model for Mantle Cell Lymphoma

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Published on: September 12, 2025

Area of Science:

Hematology
Oncology
Immunophenotyping

Background:

Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous malignancy with distinct subtypes.
The stability of cell-of-origin (COO) features in DLBCL over extended disease courses is not well understood.
Long-term patient data is essential for understanding disease evolution.

Purpose of the Study:

To investigate the potential for immunophenotypic and molecular evolution in DLBCL over a prolonged period.
To determine if the cell-of-origin profile of DLBCL remains static during repeated relapses and treatments.
To highlight the importance of reassessing DLBCL characteristics at relapse.

Main Methods:

A single patient case study with a diagnosis of DLBCL spanning over three decades (1988-2019).
Serial histopathological and immunophenotypic evaluations were performed throughout the patient's disease course and multiple relapses.
Treatment history including various chemotherapy regimens and targeted therapies was documented.

Main Results:

The patient exhibited DLBCL with sequential immunophenotypic shifts from a germinal center B-cell-like (GCB) to an activated B-cell-like (ABC)/non-GCB pattern.
The disease evolved to a CD30-positive anaplastic B-cell variant in later stages.
The patient underwent multiple treatment lines for successive relapses over 31 years.

Conclusions:

DLBCL can undergo significant stepwise immunophenotypic and molecular evolution over decades.
The COO profile of DLBCL is not static and can change during the disease course.
Repeat biopsies and comprehensive re-evaluation are critical for tailoring treatment strategies to the current state of relapsed DLBCL.