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Updated: Feb 12, 2026
08:25
Radiation Planning Assistant - A Streamlined, Fully Automated Radiotherapy Treatment Planning System
Published on: April 11, 2018
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Radiation-induced alterations in the cancer microenvironment (Review)
Haiying Liu1, Xiaoping Zhu1, Zhenxing He2
1Medical College, Hexi University, Zhangye, Gansu 734000, P.R. China.
Medicine International
|February 11, 2026
Summary
Radiation therapy resistance in cancer cells is linked to metabolic changes that affect the tumor microenvironment. Combining radiotherapy with metabolic treatments may improve cancer therapy effectiveness.
Area of Science:
- Oncology
- Cancer Metabolism
- Radiotherapy
Background:
- Radiation therapy is a cornerstone of cancer treatment, but radiation resistance limits its efficacy.
- Cancer cells exhibit metabolic reprogramming post-radiation to enhance survival and adapt.
- These metabolic shifts influence the tumor microenvironment, potentially promoting cancer cell proliferation.
Purpose of the Study:
- To review metabolic reprogramming in cancer cells after radiotherapy.
- To discuss the metabolic characteristics of the tumor microenvironment post-radiation.
- To introduce novel findings on nano-confinements impacting cancer microenvironment and metabolism.
Main Methods:
- Literature review on cancer cell metabolism and radiotherapy.
- Analysis of studies on tumor microenvironment metabolic changes.
- Discussion of emerging research on nano-confinements and their mechanisms.
Main Results:
- Radiation exposure induces significant metabolic alterations in cancer cells.
- Metabolic changes in cancer cells impact the tumor microenvironment.
- Nano-confinements present a novel mechanism influencing cancer metabolism and signaling.
Conclusions:
- Targeted metabolic interventions combined with radiotherapy show promise for enhancing cancer treatment.
- Understanding radiation-induced metabolic reprogramming is crucial for overcoming resistance.
- Nano-confinement strategies offer new avenues for modulating the tumor microenvironment and improving therapeutic outcomes.
Keywords:
metabolitenanoconfinementnanotechnologyradio-biological responseradiotherapytumor microenvironmentMore Related Videos
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