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Bronchiectasis in severe α1-antitrypsin deficiency: lessons for the pulmonologist
Christine J Kang1, Pamela J McShane2
1Division of Pulmonary and Critical Care Medicine, University of Texas Health Science Center at Tyler, Tyler, TX, USA.
Insights
Heterogeneity in bronchiectasis is observed within alpha-1-antitrypsin (α1-AT) deficiency. Broader screening is crucial for timely access to new therapies and research participation for patients with α1-AT deficiency.
Area of Science:
- Pulmonology
- Genetics
- Medical Screening
Background:
- Alpha-1-antitrypsin (α1-AT) deficiency is a genetic disorder that can lead to lung disease, including bronchiectasis.
- Bronchiectasis, a condition characterized by irreversible airway dilation, presents with varied manifestations in patients with α1-AT deficiency.
Abstract:
There is heterogeneity of bronchiectasis within α1-AT deficiency; hence, there is a need for broader screening strategies to ensure timely access to emerging therapies and inclusion in ongoing research efforts https://bit.ly/4nCZsxM.
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