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Updated: Feb 12, 2026

Application of Microwave Ablation in Laparoscopic Partial Splenectomy
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Evaluating microwave ablation for treating large benign thyroid nodules.

Yinzhu Zhao1, Fu Jin1,2, Ting Chang1

  • 1Department of Ultrasound, The First Affiliated Hospital of the University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.

Gland Surgery
|February 11, 2026
PubMed
Summary
This summary is machine-generated.

Microwave ablation (MWA) effectively treats large benign thyroid nodules (BTNs) with an 82.54% volume reduction. Repeat ablation is key to preventing recurrent laryngeal nerve injury during MWA for BTNs.

Keywords:
Thyroid nodulesablationrecurrent laryngeal nerve (RLN)ultrasonography

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Area of Science:

  • Interventional Radiology
  • Thyroidology
  • Oncology

Background:

  • Large benign thyroid nodules (≥4 cm) present treatment challenges due to proximity to critical structures.
  • Microwave ablation (MWA) offers a non-surgical option for large benign thyroid nodules (BTNs).
  • MWA's ability to achieve high intratumoral temperatures makes it a promising treatment modality.

Purpose of the Study:

  • To evaluate the efficacy and safety of MWA for large BTNs.
  • To explore strategies for preventing recurrent laryngeal nerve (RLN) injury during MWA.

Main Methods:

  • Retrospective analysis of 205 patients with large BTNs treated with MWA.
  • Clinical and ultrasound assessments at 1, 6, and 12 months post-ablation.
  • Analysis of volume reduction rate (VRR), influencing factors, and complications.

Main Results:

  • Mean nodule size was 46.56 mm; mean volume was 22.91 mL.
  • At 12 months, mean VRR was 82.54% with a 93.66% technical efficacy rate.
  • Transient hoarseness occurred in one patient; 18 cases required repeat ablation due to isolating fluid issues.

Conclusions:

  • MWA is a safe and effective treatment for large BTNs.
  • Secondary ablation is crucial for preventing RLN injury when isolating fluid is insufficient.
  • MWA demonstrates significant efficacy in reducing large benign thyroid nodule volumes.