Related Experiment Video

Updated: Feb 12, 2026

Investigating von Willebrand Factor Pathophysiology Using a Flow Chamber Model of von Willebrand Factor-platelet String Formation
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Investigating von Willebrand Factor Pathophysiology Using a Flow Chamber Model of von Willebrand Factor-platelet String Formation

Published on: August 14, 2017

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Prediction of Functional Outcomes at Discharge Using Plasma Concentration of von Willebrand Factor Antigen at

Masayuki Oki1, Daisuke Yamasawa1, Shinichi Goto1

  • 1Division of General Internal Medicine and Family Medicine, Department of General and Acute Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan.

Annals of Vascular Diseases
|February 11, 2026
PubMed

Insights

Elevated von Willebrand factor (VWF) levels at hospital admission predict poor functional outcomes in patients with Coronavirus disease 2019 (COVID-19) after discharge. This finding is independent of patient age and sex.

Area of Science:

  • Vascular Medicine
  • Immunothrombosis
  • Biomarkers

Background:

  • Coronavirus disease 2019 (COVID-19) can cause endothelial injury, leading to vascular dysfunction and immunothrombosis.
  • Plasma von Willebrand factor (VWF) levels are recognized biomarkers of vascular injury.
  • The predictive value of VWF for post-discharge functional outcomes in COVID-19 patients is not well-established.

Purpose of the Study:

  • To investigate the association between plasma VWF antigen (VWF:Ag) levels at hospital admission and functional status at discharge in COVID-19 patients.
  • To determine if VWF:Ag is an independent predictor of poor functional outcomes post-discharge.

Main Methods:

  • A single-center prospective cohort study was conducted with 97 hospitalized COVID-19 patients.
  • Plasma VWF:Ag levels were measured at admission.
  • Functional status at discharge was assessed using the Clinical Frailty Scale (CFS).
  • Univariable and multivariable logistic regression analyses were employed.

Main Results:

  • The median VWF:Ag level at admission was 330.0%.
  • Elevated VWF:Ag levels were significantly associated with a CFS score ≥4 at discharge in univariable analysis.
  • This association remained statistically significant after adjusting for age and sex (OR 1.010, p=0.005).

Conclusions:

  • Elevated plasma VWF:Ag levels at admission are a significant predictor of poor functional outcomes at discharge in COVID-19 patients.
  • VWF:Ag serves as an independent prognostic biomarker for functional recovery after COVID-19 hospitalization.
  • These findings highlight the role of VWF in COVID-19-related vascular injury and long-term outcomes.
Abstract

Keywords:
ADAMTS13COVID-19endothelial injuryfunctional outcomevon Willebrand factor

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