Related Experiment Video
Updated: Feb 12, 2026
08:36
A Versatile Murine Model of Subcortical White Matter Stroke for the Study of Axonal Degeneration and White Matter Neurobiology
Published on: March 17, 2016
8.6K
Intersecting vulnerabilities: race, depression, and white matter hypointensity burden in aging
Farooq Kamal1,2, Roqaie Moqadam2, Cassandra Morrison3
1Department of Psychiatry McGill University Montreal Quebec Canada.
Alzheimer'S & Dementia (Amsterdam, Netherlands)
|February 11, 2026
Summary
Depression exacerbates white matter hypointensities (WMHs) and cognitive decline in Black and Hispanic older adults, but not in White older adults. Race and depression interact to affect cerebrovascular disease burden and cognitive function.
Area of Science:
- Neuroscience
- Gerontology
- Public Health
Background:
- White matter hypointensities (WMHs) are linked to cognitive decline and dementia.
- The influence of race, ethnicity, and depression on WMHs is not well understood.
Purpose of the Study:
- To investigate the combined effects of race/ethnicity and depression on WMHs.
- To examine how these factors impact cognitive function in older adults.
Main Methods:
- Utilized data from 2411 older adults from the National Alzheimer's Coordinating Center.
- Employed linear regressions to analyze WMH burden and cognitive associations across racial/ethnic and depression groups.
Main Results:
- Black and Hispanic older adults with depression exhibited greater WMH burden compared to those without depression.
- Depression significantly altered the association between WMHs and cognitive impairment in Black and Hispanic individuals.
- These effects were not observed in White older adults.
Conclusions:
- Race and depression may interact to influence cerebrovascular disease burden.
- This interaction may also affect the relationship between WMHs and cognition in aging and dementia.
Related Concept Videos
02:49Classifying Matter by State
104.6K
Chemistry is the study of matter and the changes it undergoes. Matter is anything that has mass and occupies space. Matter is all around us; the air, water, soil, mountains, even our bodies are all examples of matter. Matter is divided into three states — solid, liquid, and gas — that are commonly found on earth. The fourth state of matter, plasma, occurs naturally in the interiors of stars.
104.6K
01:05Long-term Depression
33.4K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
33.4K
03:35Classifying Matter by Composition
91.5K
Matter: Pure Substances and Mixtures
According to its composition, the matter can be classified into two broad categories — pure substances and mixtures.
A pure substance is a form of matter that has a constant composition throughout with uniform properties. For example, any sample of sucrose has the same composition and same physical properties, such as melting point, color, and sweetness, regardless of the source from which it is isolated.
A mixture is composed of two or...
According to its composition, the matter can be classified into two broad categories — pure substances and mixtures.
A pure substance is a form of matter that has a constant composition throughout with uniform properties. For example, any sample of sucrose has the same composition and same physical properties, such as melting point, color, and sweetness, regardless of the source from which it is isolated.
A mixture is composed of two or...
91.5K
02:57Physical and Chemical Properties of Matter
167.1K
The characteristics that enable us to distinguish one substance from another are called properties.
167.1K
02:35RACE - Rapid Amplification of cDNA Ends
7.3K
Rapid Amplification of cDNA Ends, or RACE, is one of the most effective methods to obtain a full-length cDNA from an mRNA sequence between a known internal region to the unknown sequence at the 5’ or 3’ end. The unknown region is cloned in the cDNA by a gene-specific primer that binds the known end, and a hybrid primer that attaches a predefined anchor sequence to the unknown end of the cDNA. The sequence in between is amplified by PCR with an anchor primer and a gene-specific...
7.3K
03:12Freezing Point Depression and Boiling Point Elevation
40.5K
Boiling Point Elevation
The boiling point of a liquid is the temperature at which its vapor pressure is equal to ambient atmospheric pressure. Since the vapor pressure of a solution is lowered due to the presence of nonvolatile solutes, it stands to reason that the solution’s boiling point will subsequently be increased. Vapor pressure increases with temperature, and so a solution will require a higher temperature than will pure solvent to achieve any given vapor pressure, including one...
The boiling point of a liquid is the temperature at which its vapor pressure is equal to ambient atmospheric pressure. Since the vapor pressure of a solution is lowered due to the presence of nonvolatile solutes, it stands to reason that the solution’s boiling point will subsequently be increased. Vapor pressure increases with temperature, and so a solution will require a higher temperature than will pure solvent to achieve any given vapor pressure, including one...
40.5K