Maternal Consumption of Nano-Ginger: Implications for Fetal Development and Organogenesis in Rat Models

Ginger, owing to its pharmacological properties, has garnered attention for its potential teratogenic effects during pregnancy, particularly throughout the period of organogenesis. In this study, we aimed to evaluate the effects of nano-ginger on fetal organogenesis in pregnant rat following administration of a nano-ginger solution.

In total, 230 pregnant female rat were divided into three groups, each consisting of 22 rat. The first group received 50 mg/kg of PAMOR Rally orally, the second group received 500 mg/kg, and the third group received 1000 mg/kg. Throughout the treatment period, the subjects' body weight, food intake, and water consumption were monitored. On the 21^st day of gestation, reproductive performance was assessed using the methods described below. The fetuses were examined for signs of teratogenicity and toxicity.

There were no deaths or unfavorable outcomes linked to the treatment. Nano-ginger treatment did not affect the reproductive performance in any way. There were no signs of embryotoxicity as well as teratogenicity for exterior, visceral, and structural morphological changes on the embryos at 40 weeks of developmental age.

These findings suggest that nano-ginger influences the organogenesis of fetuses in pregnant rat that were given nano-ginger solution throughout organogenesis. Nonetheless, it is non-toxic to the mother or embryonic/fetal development regardless of their depositing daily doses of up to 1000 mg/kg body weight.