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Related Experiment Video

Updated: Feb 12, 2026

Inducing Post-Traumatic Epilepsy in a Mouse Model of Repetitive Diffuse Traumatic Brain Injury
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Brivaracetam Use in Managing Seizures Following Traumatic Brain Injury.

Alisha Ali1, Zanib Javed2, Ahsan Ali Khan2

  • 1Neurosurgery, Aga Khan University Hospital, Karachi, PAK.

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|February 11, 2026
PubMed
Summary

Brivaracetam (BRV) and levetiracetam (LEV) show similar effectiveness in preventing seizures after traumatic brain injury (TBI). BRV demonstrated better neurobehavioral outcomes, suggesting improved tolerability for TBI patients.

Keywords:
brivaracetamlevetiracetamneurobehavioral outcomespost-traumatic seizuresseizure prophylaxistraumatic brain injury

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Trauma Care

Background:

  • Traumatic brain injury (TBI) is a significant global health issue, often leading to post-traumatic seizures (PTS).
  • Levetiracetam (LEV) is a common prophylaxis for PTS but can cause adverse behavioral effects.
  • Brivaracetam (BRV), a newer antiseizure drug with higher synaptic vesicle 2A (SV2A) binding, is explored for better tolerability.

Purpose of the Study:

  • To compare the efficacy and neurobehavioral outcomes of BRV versus LEV in patients with TBI.
  • To assess the effectiveness of BRV and LEV in preventing early and late post-traumatic seizures.
  • To evaluate the impact of BRV and LEV on functional recovery and neurobehavioral symptoms post-TBI.

Main Methods:

  • A prospective cohort study involving 132 adult TBI patients followed for six months.
  • Patients were assigned to receive either BRV or LEV based on physician discretion.
  • Outcomes included seizure occurrence (early/late PTS), functional recovery (GOSE), and neurobehavioral symptoms (NSI).

Main Results:

  • Seizure incidence was comparable between BRV (16.6%) and LEV (25.7%) groups (p=0.20).
  • No significant differences were observed in Glasgow Outcome Scale-Extended (GOSE) scores between the groups.
  • BRV treatment resulted in significantly lower Neurobehavioral Symptom Inventory (NSI) scores at 14 days and 3 months post-TBI compared to LEV.

Conclusions:

  • BRV and LEV exhibit comparable efficacy in preventing PTS in TBI patients, though the study was underpowered to detect significant differences in seizure rates.
  • BRV was associated with significantly improved neurobehavioral outcomes, particularly in the early recovery phase.
  • BRV may represent a more tolerable option for seizure prophylaxis following TBI, warranting further investigation in larger studies.