The Role of 68Ga-Pentixafor and 18F-Fluorodeoxyglucose (18F-FDG) PET/CT in a Case of Multiple Myeloma

Abhishek Kumar1, Tamojit Chaudhuri2, Manisha Pradhan3

  • 1Nuclear Medicine, Tata Main Hospital, Jamshedpur, IND.

Cureus
|February 11, 2026
PubMed

Insights

This case report compares two positron emission tomography (PET) radiotracers for staging multiple myeloma (MM). 18F-fluorodeoxyglucose (FDG) and C-X-C chemokine receptor type 4 (CXCR4) targeting Pentixafor show potential for MM detection and staging.

Area of Science:

  • Oncology
  • Nuclear Medicine
  • Radiochemistry

Background:

  • Multiple myeloma (MM) is a plasma cell malignancy originating in the bone marrow.
  • Diagnosis and staging of MM typically involve blood/urine tests and imaging.
  • Positron emission tomography (PET) is a key imaging modality for MM staging.

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