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Relationship between Multiple HPV Infections and Cervical Cytology: Single Center Experience.

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Multiple human papillomavirus (HPV) infections are linked to more cervical cell abnormalities. High-risk HPV infections significantly increase the risk of high-grade lesions, emphasizing tailored screening strategies.

Keywords:
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Area of Science:

  • Gynecology
  • Oncology
  • Virology

Background:

  • Cervical cancer is a major public health issue globally.
  • Persistent high-risk human papillomavirus (HPV) infections are a primary cause.
  • Understanding HPV infection patterns is crucial for prevention and management.

Purpose of the Study:

  • To investigate the association between multiple HPV infections and cervical cytology abnormalities.
  • To analyze the prevalence of different HPV genotypes and their correlation with cytological outcomes.
  • To assess the impact of high-risk HPV (HRHPV) co-infections on lesion severity.

Main Methods:

  • Retrospective analysis of 6,869 HPV genotyping tests from January 2017 to December 2023.
  • Analysis of 1,396 HPV-positive cases, focusing on genotype prevalence and co-infections.
  • Correlation of HPV infection status (single, multiple, HRHPV) with squamous intraepithelial abnormalities (SIA).

Main Results:

  • High-risk HPV (HRHPV) detected in 59.0% of HPV-positive cases; HPV 53 was most common.
  • Squamous intraepithelial abnormalities (SIA) frequency increased with the number of concurrent HPV infections (24.2% for single to 70.0% for four).
  • HRHPV-positive cases showed a higher prevalence of high-grade lesions (ASC-H, HSIL) compared to non-HRHPV and HPV-negative cases.

Conclusions:

  • Multiple HPV infections are associated with increased cytological abnormalities, especially in HRHPV-positive individuals.
  • Prevalence of HPV genotypes varies regionally, necessitating customized vaccination and screening.
  • Further research is needed due to the study's retrospective design and limited follow-up.