Related Experiment Video
Updated: Feb 12, 2026
07:26
Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents
Published on: July 14, 2021
5.6K
Do Early Aortic Remodelling Patterns at 6 Months Predict Mid-Term Outcomes After Frozen Elephant Trunk for Chronic
Sho Akita1,2, Yoshiyuki Tokuda1, Akinori Tamenishi2
1Department of Cardiac Surgery, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8560, Japan.
Interdisciplinary Cardiovascular and Thoracic Surgery
|February 11, 2026
Summary
Computed tomography (CT) after frozen elephant trunk (FET) repair for aortic dissection predicts outcomes. Early negative remodeling (ENR) on 6-month CT indicates a high-risk group needing closer surveillance and timely intervention.
Area of Science:
- Cardiovascular Surgery
- Thoracic Surgery
- Aortic Surgery
Background:
- Chronic aortic dissection poses significant risks, often requiring complex surgical repair.
- Total arch replacement with a frozen elephant trunk (FET) is a key intervention for extensive aortic disease.
- Predicting mid-term outcomes after FET repair is crucial for guiding further management.
Purpose of the Study:
- To evaluate the predictive value of 6-month postoperative computed tomography (CT) after FET repair for chronic aortic dissection.
- To determine if early aortic remodeling on CT can stratify risk and inform the timing of distal interventions.
Main Methods:
- Analysis of 56 patients undergoing total arch replacement with FET, with 6-month postoperative CT scans.
- Definition of early positive remodeling (EPR) and early negative remodeling (ENR) based on proximal descending thoracic aorta diameter changes.
- Assessment of outcomes including distal reintervention, stent graft-induced new entry (dSINE), and overall survival.
Main Results:
- Patients with ENR showed significantly higher rates of distal reintervention (6.2% vs 44.6% freedom from reintervention) and dSINE (18.2% vs 65.1% dSINE-free survival) at 5 years compared to EPR.
- Overall 5-year survival was 80.0% for the cohort.
- In the ENR group, 5-year survival was 0% with conservative management versus 40.5% with distal intervention, while in the EPR group, survival was 65.9% with conservative management vs 85.7% with reintervention.
Conclusions:
- Six-month CT imaging after FET repair provides a simple and actionable method for risk stratification in chronic aortic dissection.
- The absence of early positive remodeling (ENR) identifies a high-risk subgroup requiring intensified surveillance and prompt distal treatment.
- This imaging-based risk assessment can optimize follow-up intensity and the timing of subsequent interventions.
Related Concept Videos
02:24Predicting Reaction Outcomes
11.0K
Kinetics describes the rate and path by which a reaction occurs. In contrast, thermodynamics deals with state functions and describes the properties, behavior, and components of a system. It is not concerned with the path taken by the process and cannot address the rate at which a reaction occurs. Although it does provide information about what can happen during a reaction process, it does not describe the detailed steps of what appears on an atomic or a molecular level. On the other hand,...
11.0K
01:15Aortic Regurgitation I: Introduction
696
IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
696
01:17Aortic Regurgitation IV: Nursing Management
329
A nurse managing a patient with aortic regurgitation begins with a comprehensive assessment, including a review of the patient's medical history, family history, and lifestyle factors. During the cardiac examination, the nurse listens for heart sounds and checks for signs of valve abnormalities. The nurse also observes for symptoms such as dyspnea, orthopnea, and paroxysmal nocturnal dyspnea and assesses the patient's endurance and daily activity tolerance.Based on the findings, the nurse...
329
01:25Aortic Regurgitation III: Medical Management
467
Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...
467
02:54Nucleosome Remodeling
11.3K
Nucleosomes are the basic units of chromatin compaction. Each nucleosome consists of the DNA bound tightly around a histone core, which makes the DNA inaccessible to DNA binding proteins such as DNA polymerase and RNA polymerase. Hence, the fundamental problem is to ensure access to DNA when appropriate, despite the compact and protective chromatin structure.
Nucleosome remodeling complex
Eukaryotic cells have specialized enzymes called ATP-dependent nucleosome remodeling enzymes. These enzymes...
Nucleosome remodeling complex
Eukaryotic cells have specialized enzymes called ATP-dependent nucleosome remodeling enzymes. These enzymes...
11.3K
01:22Aortic Regurgitation II: Clinical Features and Diagnostic Tests
568
Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
568