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Related Experiment Video

Updated: Feb 12, 2026

Measurement of the Hand Transmitted Vibration of the Human Hand Arm System During Operation of a Hand Tractor
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Calcium Hydroxyapatite and Polymicronutrient Solution on Hand Rejuvenation: A Split-Hand, Randomized, Double-Blind

Gladstone Eustáquio de Lima Faria1, Cibele Hasmann2, Renata M M Viana3

  • 1Instituto Boggio, São Paulo, São Paulo, Brazil.

Journal of Cosmetic Dermatology
|February 11, 2026
PubMed
Summary
This summary is machine-generated.

Calcium hydroxyapatite (CaHA) combined with polymicronutrients (PMN) showed enhanced in vitro biological activity compared to CaHA in saline. Clinically, both CaHA + PMN and CaHA + saline provided comparable hand rejuvenation results.

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Area of Science:

  • Dermatology and Aesthetic Medicine
  • Biomaterials Science
  • Cellular Biology

Background:

  • Calcium hydroxyapatite (CaHA) is an FDA-approved biostimulatory filler for hand rejuvenation.
  • Polymicronutrient (PMN) solutions are explored for enhancing cellular metabolism and extracellular matrix (ECM) regeneration with CaHA.

Purpose of the Study:

  • To compare the biological and clinical effects of CaHA diluted in PMN solution versus saline solution for hand rejuvenation.
  • To evaluate fibroblast proliferation, ECM gene expression, and clinical outcomes of CaHA formulations.

Main Methods:

  • In vitro: Assessed fibroblast proliferation and ECM gene expression (COL1A1, COL3A1, ELN) after exposure to CaHA + PMN or CaHA + saline.
  • Clinical: Prospective, split-hand, double-blind trial (n=22) evaluated Hand Grading Scale (HGS), Global Aesthetic Improvement Scale (GAIS), skin hydration, and dermal thickness.

Main Results:

  • In vitro: CaHA + PMN demonstrated increased fibroblast proliferation and upregulated COL1A1 and ELN gene expression compared to CaHA + saline.
  • Clinically: Both formulations significantly improved HGS, skin hydration, and dermal thickness without significant between-group differences.
  • Both investigator-assessed GAIS and patient satisfaction improved in both groups.

Conclusions:

  • CaHA + PMN and CaHA + saline yielded comparable clinical outcomes for hand rejuvenation.
  • In vitro results suggest CaHA + PMN has enhanced biological activity, warranting further investigation.
  • The potent biostimulatory effect of CaHA may mask additive benefits of PMN in clinical settings.