Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nursing Implementation01:15

Nursing Implementation

6.2K
Implementation is the execution of the nursing care plan developed during the planning phase.
The five steps to implementing effective nursing care include reassessing the patient, reviewing and revising the existing nursing care plan, organizing the resources and care delivery, anticipating and preventing complications, and implementing nursing interventions.
6.2K
Random and Systematic Errors01:20

Random and Systematic Errors

15.2K
Scientists always try their best to record measurements with the utmost accuracy and precision. However, sometimes errors do occur. These errors can be random or systematic. Random errors are observed due to the inconsistency or fluctuation in the measurement process, or variations in the quantity itself that is being measured. Such errors fluctuate from being greater than or less than the true value in repeated measurements. Consider a scientist measuring the length of an earthworm using a...
15.2K
Systematic Sampling Method01:17

Systematic Sampling Method

13.4K
Sampling is a technique to select a portion (or subset) of the larger population and study that portion (the sample) to gain information about the population. Data are the result of sampling from a population. The sampling method ensures that samples are drawn without bias and accurately represent the population. Because measuring the entire population in a study is not practical, researchers use samples to represent the population of interest.
Systematic sampling is one of the simplest methods...
13.4K
Propagation of Uncertainty from Systematic Error01:10

Propagation of Uncertainty from Systematic Error

1.5K
The atomic mass of an element varies due to the relative ratio of its isotopes. A sample's relative proportion of oxygen isotopes influences its average atomic mass. For instance, if we were to measure the atomic mass of oxygen from a sample, the mass would be a weighted average of the isotopic masses of oxygen in that sample. Since a single sample is not likely to perfectly reflect the true atomic mass of oxygen for all the molecules of oxygen on Earth, the mass we obtain from this...
1.5K
Characteristics of Practical Op Amps01:16

Characteristics of Practical Op Amps

872
A difference amplifier, a crucial component in numerous electronic devices, ideally amplifies only the difference-mode signal, which is the difference between two input signals. However, in practical circuits, the output voltage depends on both the differential gain and the common-mode gain.
The ratio of differential gain to the common-mode gain is defined as the common-mode rejection ratio (CMRR). This ratio quantifies the ability of operational amplifiers (op-amps) to reject common-mode...
872
Theoretical Foundations of Nursing Practice01:30

Theoretical Foundations of Nursing Practice

17.7K
Theories play an essential role in organizing patient care. Theories refer to a proposed or followed belief, policy, or procedure that is the basis for action. Nursing theories are knowledge-based concepts that guide nurses' actions, influence nursing education and practice, and allow nurses to care for their patients.
Theories provide a perspective to assess patients' conditions and organize data and methods. They also assist in analyzing and interpreting information. They represent a...
17.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Transpulmonary proteomic gradient analysis in women with pulmonary arterial hypertension associated with systemic sclerosis.

Journal of proteomics·2026
Same author

Strengthening animal welfare: monitoring humane endpoints in a rat model of mammary tumorigenesis undergoing a ladder resistance training protocol.

Laboratory animals·2026
Same author

Reversible podocytopathy in a patient with blastoid-variant mantle cell lymphoma: A case of paraneoplastic FSGS and a literature review.

Nefrologia·2026
Same author

Pre-Transplant Serum FTIRS Signatures as Predictive Biomarkers of Early Transient Pancreatic Graft Dysfunction in Simultaneous Pancreas-Kidney Transplantation.

Life (Basel, Switzerland)·2026
Same author

Urinary bowel stone: calculus formation in a repurposed small intestine - a case report.

BMC nephrology·2026
Same author

Development and validation of an instrument to assess public perception of cancer primary prevention information.

Archives of public health = Archives belges de sante publique·2026
Same journal

Supporting patients and family members facing treatment choices in chronic kidney disease: What do professionals think of the decision aids used? - Professionals’ views on treatment decision support tools

Nephrologie & therapeutique·2026
Same journal

From Turing to ChatGPT: The origins and transformations of medical artificial intelligence

Nephrologie & therapeutique·2026
Same journal

Analysis of the predictive value of serum Cys-C and IL-6 levels for acute kidney injury in patients with acute respiratory distress syndrome.

Nephrologie & therapeutique·2026
Same journal

Navigating pain in chronic kidney disease: Overcoming inertia!

Nephrologie & therapeutique·2026
Same journal

Kidney health for all: caring for people, protecting the planet1.

Nephrologie & therapeutique·2026
Same journal

When the heart breaks, the kidneys follow: A case of Takotsubo syndrome

Nephrologie & therapeutique·2026
See all related articles

Related Experiment Video

Updated: Feb 12, 2026

A Standardized Liquid Biopsy Preanalytical Protocol for Downstream Circulating-Free DNA Applications
05:26

A Standardized Liquid Biopsy Preanalytical Protocol for Downstream Circulating-Free DNA Applications

Published on: September 16, 2022

4.7K

Implementing systematic early protocol biopsies in routine practice: An exploratory real-world study.

Ana Rita Ramos1, Andreia Carnevale2, José Soares3

  • 1Unidade local de Saúde do Médio Tejo, Nephrology department, Hospital de Torres Novas, Portugal

Nephrologie & Therapeutique
|February 11, 2026
PubMed
Summary
This summary is machine-generated.

Protocol biopsies detect subclinical kidney transplant rejection early, allowing intervention. Higher estimated glomerular filtration rate (eGFR) at discharge predicts better long-term graft survival.

Keywords:
kidney transplantationprotocol biopsygraft survivalBanff classification

More Related Videos

Preparation and Using Phantom Lesions to Practice Fine Needle Aspiration Biopsies
09:26

Preparation and Using Phantom Lesions to Practice Fine Needle Aspiration Biopsies

Published on: September 29, 2009

18.6K
Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack
07:31

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack

Published on: May 15, 2020

8.1K

Related Experiment Videos

Last Updated: Feb 12, 2026

A Standardized Liquid Biopsy Preanalytical Protocol for Downstream Circulating-Free DNA Applications
05:26

A Standardized Liquid Biopsy Preanalytical Protocol for Downstream Circulating-Free DNA Applications

Published on: September 16, 2022

4.7K
Preparation and Using Phantom Lesions to Practice Fine Needle Aspiration Biopsies
09:26

Preparation and Using Phantom Lesions to Practice Fine Needle Aspiration Biopsies

Published on: September 29, 2009

18.6K
Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack
07:31

Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack

Published on: May 15, 2020

8.1K

Area of Science:

  • Nephrology
  • Transplant Surgery
  • Immunology

Background:

  • Acute rejection is a primary threat to kidney transplant long-term graft survival.
  • Subclinical rejection often goes undetected without histological assessment, leading to progressive graft injury.
  • Early detection and intervention are crucial for preserving graft function.

Purpose of the Study:

  • To evaluate the role of protocol biopsies in detecting subclinical rejection.
  • To assess the impact of early intervention on graft function.
  • To examine the prognostic significance of early histological findings and discharge estimated glomerular filtration rate (eGFR).

Main Methods:

  • Retrospective, single-center study of kidney transplant recipients.
  • Analysis of clinical, immunological, and histopathological data from early protocol biopsies.
  • Assessment of Banff inflammatory scores, renal function (eGFR), and long-term outcomes.

Main Results:

  • Rejection was detected in 20.2% of patients, primarily T-cell mediated.
  • Early intervention significantly improved renal function (mean eGFR increase from 36.0 to 51.0 mL/min/1.73 m²).
  • Higher discharge eGFR was strongly associated with better long-term renal function.

Conclusions:

  • Protocol biopsies are essential for early detection of subclinical rejection, facilitating timely intervention.
  • Discharge eGFR is a strong predictor of long-term kidney transplant outcomes.
  • Prompt management of rejection improves graft survival.