Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

1.0K
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
1.0K
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

4.0K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
4.0K
Heart Failure I: Introduction01:27

Heart Failure I: Introduction

951
Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
951
Regression Toward the Mean01:52

Regression Toward the Mean

7.2K
Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when...
7.2K
Heart Failure VI: Adjunct Therapies01:22

Heart Failure VI: Adjunct Therapies

395
Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
395
Heart Failure Drugs: Diuretics01:22

Heart Failure Drugs: Diuretics

1.0K
Heart failure and kidney perfusion are interconnected in a complex way. Reduced renal perfusion and venous congestion are two significant factors that contribute to renal dysfunction in heart failure. The kidneys, primarily responsible for fluid balance in the body, are adversely affected due to compromised cardiac output and increased venous pressure. In response to reduced renal perfusion, the kidneys activate neurohumoral mechanisms to restore balance. However, these mechanisms can be...
1.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Impact of the Social Determinants of Health on Women with Heart Failure in Europe: a Scoping Review.

European journal of cardiovascular nursing·2026
Same author

Prediction of hospitalisation in young children with pneumonia in Malawi: A machine learning-based approach.

PLoS medicine·2026
Same author

The United Kingdom National Programme of DCD heart transplantation: Timings, techniques, feasibility, and outcomes with abdominal normothermic regional perfusion.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation·2026
Same author

Do we need exercise echocardiography to diagnose HFpEF? Not at all.

European journal of heart failure·2026
Same author

Investigation of Biomarker Response to SGLT2 Inhibition in Heart Failure (SiN-HF).

Cardiovascular drugs and therapy·2025
Same author

Heart Failure Diagnosis and Severity Estimation enhanced by Generative Adversarial Network.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
Same journal

Stable, Progressive, and Acute Valve Syndrome in Severe Aortic Stenosis: Insights from the CURRENT AS Registry-2.

Journal of the American Heart Association·2026
Same journal

<i>LPA</i> Kringle IV Type-2 Genetic Variants Are Associated With Apolipoprotein (a) Size, Hypertension, and Nonfasting Glucose Levels.

Journal of the American Heart Association·2026
Same journal

Hemorrhagic Transformation Mediates Stress Hyperglycemia Effect on Functional Outcome in Minor Ischemic Stroke.

Journal of the American Heart Association·2026
Same journal

Mental Disorders After Cardiac Implantable Electronic Device Implantation in Young Individuals.

Journal of the American Heart Association·2026
Same journal

Hypertensive Disorders of Pregnancy Associated With Cerebral Small Vessel Disease Decades Later.

Journal of the American Heart Association·2026
Same journal

Neighborhood-Level Racial and Ethnic Residential Segregation and Incidence of Atrial Fibrillation: The Multi-Ethnic Study of Atherosclerosis.

Journal of the American Heart Association·2026
See all related articles

Related Experiment Video

Updated: Feb 12, 2026

Gene Transfer for Ischemic Heart Failure in a Preclinical Model
07:35

Gene Transfer for Ischemic Heart Failure in a Preclinical Model

Published on: May 15, 2011

13.4K

Preclinical Heart Failure: A Dynamic Trajectory of Progression, Regression, and Risk.

Ashe Moore1, Bethany Wong1, Alice Brennan1

  • 1Department of Cardiology, St Vincent's Healthcare Group and Innovation Centre for Chronic Disease University College Dublin Dublin Ireland.

Journal of the American Heart Association
|February 11, 2026
PubMed
Summary
This summary is machine-generated.

Preclinical heart failure progression is bidirectional, with opportunities for regression and stability. Natriuretic peptide screening improves risk stratification for heart failure prevention.

Keywords:
biomarkersnatural historypreclinical heart failure

More Related Videos

Establishing a Competing Risk Regression Nomogram Model for Survival Data
04:57

Establishing a Competing Risk Regression Nomogram Model for Survival Data

Published on: October 23, 2020

10.9K
Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach
07:49

Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach

Published on: July 21, 2023

2.0K

Related Experiment Videos

Last Updated: Feb 12, 2026

Gene Transfer for Ischemic Heart Failure in a Preclinical Model
07:35

Gene Transfer for Ischemic Heart Failure in a Preclinical Model

Published on: May 15, 2011

13.4K
Establishing a Competing Risk Regression Nomogram Model for Survival Data
04:57

Establishing a Competing Risk Regression Nomogram Model for Survival Data

Published on: October 23, 2020

10.9K
Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach
07:49

Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach

Published on: July 21, 2023

2.0K

Area of Science:

  • Cardiology
  • Preventive Medicine
  • Biomarker Research

Background:

  • Understanding preclinical heart failure progression is key for prevention.
  • Biomarker and echocardiographic changes are critical during this transition.

Purpose of the Study:

  • To analyze the trajectory of preclinical heart failure.
  • To assess the role of B-type natriuretic peptide (BNP) and echocardiography in predicting progression and regression.

Main Methods:

  • Retrospective cohort study of 1425 participants from the STOP-HF trial.
  • Median follow-up of 4.5 years with serial assessments of BNP and Doppler echocardiography.
  • Participants classified as stage A (at risk) or stage B (asymptomatic abnormalities).

Main Results:

  • 22% of stage A progressed to stage B; 10% of stage B progressed to symptomatic stage C.
  • Stage A progressors had higher baseline BNP compared to non-progressors.
  • 18% of stage B regressed to stage A, showing lower baseline BNP and favorable echocardiographic features.

Conclusions:

  • Preclinical heart failure shows a bidirectional trajectory, with potential for regression and stability.
  • Natriuretic peptide screening enhances risk stratification for preventive interventions.
  • Findings support the integration of BNP screening into heart failure prevention strategies.