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Prevalence of Cerebral Microbleeds and Association With Vascular Risk Factors in a Hispanic and Latino American

Vladimir Ivanovic1, Elmira Agah1, Stephan Seiler1

  • 1Department of Neurology University of California Davis School of Medicine Sacramento CA USA.

Journal of the American Heart Association
|February 11, 2026
PubMed
Abstract

Insights

High vascular risk and stroke history are linked to cerebral microbleeds (CMBs) in Hispanic and Latino adults. Cognitive impairment also increases the likelihood of CMBs, particularly in deep brain regions.

Area of Science:

  • Neurology
  • Neuroimaging
  • Public Health

Background:

  • Cerebral microbleeds (CMBs) are small vascular lesions in the brain.
  • Their prevalence and associations in diverse populations like Hispanic and Latino individuals require further investigation.
  • Understanding CMBs is crucial for assessing cerebrovascular health and cognitive decline.

Purpose of the Study:

  • To estimate the prevalence and number of CMBs in a diverse Hispanic and Latino cohort.
  • To investigate associations between CMBs and demographic factors, vascular risk, APOE genotype, and cognitive function.

Main Methods:

  • Utilized 3T brain magnetic resonance imaging (MRI) from the SOL-INCA-MRI study.
  • Quantified and categorized CMBs into lobar, deep, and mixed locations.
  • Examined associations with age, sex, education, cardiovascular risk factors, APOE genotype, and cognitive status.

Main Results:

  • CMB prevalence was 11.7% in 2455 participants (mean age 63.0 years, 67.9% women).
  • High Framingham Risk Score correlated with CMB presence (except lobar only).
  • Cognitive impairment was associated with higher prevalence of mixed CMBs and increased total CMB count.

Conclusions:

  • Elevated vascular risk scores and history of stroke/transient ischemic attack are associated with increased likelihood of CMBs.
  • Cognitive status is significantly linked to a higher prevalence of CMBs, especially in deep brain regions.
  • Findings highlight the importance of vascular health and cognitive function in relation to CMBs within this cohort.
Keywords:
Hispanic and Latino heritagecerebral microbleedscognitive functionvascular risk factors

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