Poly(D,L-lactide)-grafted Cu-doped bioactive glass microspheres as core-shell building blocks for biomaterials: from grafting to early-stage in vitro behaviour
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View abstract on PubMed
Summary
This summary is machine-generated.Researchers developed novel core-shell microparticles by grafting poly(D,L-lactide) onto copper-doped bioactive glass. This innovation enhances bone scaffold fabrication by controlling ion release and improving cell compatibility while maintaining antibacterial properties.
Area Of Science
- Biomaterials Science
- Materials Chemistry
- Tissue Engineering
Background
- Freeze-casting is a promising technique for creating porous bone scaffolds.
- Achieving homogeneous dispersion of bioactive glass (BG) within polymer solutions for scaffolds is a significant challenge.
- Controlling the release of ions from BG is crucial for optimizing biological responses and avoiding detrimental effects.
Purpose Of The Study
- To synthesize novel core-shell microparticles combining copper-doped bioactive glass (Cu-BG) with poly(D,L-lactide) (PDLLA).
- To investigate the effect of PDLLA grafting on the degradation, ion release, and biological performance of Cu-BG.
- To evaluate the potential of these modified microspheres as building blocks for freeze-castable bone scaffolds.
Main Methods
- Surface-initiated "grafting from" polymerization to attach PDLLA to Cu-BG.
- Fourier-transform infrared (FT-IR) spectroscopy and thermogravimetric analysis (TGA) to confirm covalent grafting.
- Simulated body fluid (SBF) immersion to assess degradation and ion release kinetics.
- In vitro cytotoxicity and antibacterial assays to evaluate biological performance.
Main Results
- Successful synthesis of PDLLA-grafted Cu-BG core-shell microparticles with confirmed covalent bonding.
- PDLLA corona effectively delayed the degradation of BG and mitigated the initial burst release of ions, especially Cu2+.
- PDLLA-grafted particles demonstrated improved cytocompatibility and preserved antibacterial activity compared to unmodified BG.
- PDLLA-BG5 formulation exhibited an optimal balance between bacterial inhibition and cellular viability.
Conclusions
- Polymer-grafted, Cu-doped BG microspheres offer a viable strategy to overcome dispersion challenges in freeze-casting.
- These core-shell microparticles provide controlled ion release, enhancing cytocompatibility while retaining therapeutic antibacterial effects.
- The developed microspheres are promising building blocks for advanced PDLLA-based bone scaffolds with tunable biological responses.
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