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Updated: Feb 12, 2026

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery

Role of Diffusion MRI Tractography in Endoscopic Endonasal Skull Base Surgery

Published on: July 5, 2021

Skull Base Surgery in the Pediatric Population-The 2nd International Collaborative Study (1995-2015).

Dan M Fliss¹, Omer J Ungar^2,3, Helena Levyn⁴

¹Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.

|February 11, 2026

Summary

This summary is machine-generated.

This global review of pediatric skull base tumors found sarcoma to be most common. Negative margins and adjuvant radiotherapy improved survival, while dural invasion worsened outcomes.

Keywords:

global collaboration multimodality treatment pediatric skull base tumors prognostic factors survival outcomes

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Published on: November 1, 2007

Area of Science:

Pediatric Oncology
Neurosurgery
Skull Base Tumors

Background:

Global review of malignant skull base tumors in children.
Data from 28 institutions on 3061 patients, including 64 pediatric cases (2.1%).

Purpose of the Study:

To review the management and outcomes of pediatric skull base malignancies.
Identify factors influencing survival in this population.

Main Methods:

Retrospective analysis of clinical variables and survival outcomes (OS and DFS).
Multivariable analysis to identify prognostic factors.
Evaluation of surgical approaches, including open, endoscopic, and combined techniques.

Main Results:

Sarcoma was the most frequent malignancy (57.8%), followed by esthesioneuroblastoma (25.0%) and carcinoma (17.2%).
Achieving negative surgical margins was associated with better outcomes (53.1% of cases).
Dural invasion correlated with reduced overall survival (OS) and disease-free survival (DFS); adjuvant radiotherapy improved survival.

Conclusions:

Open surgical approaches were prevalent, but endoscopic techniques increased by 2015.
Results reflect a transitional period with expanding use of endoscopic skull base surgery in pediatric oncology.