Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Design Example: Analyzing Capacity Contours for Flood Risk Assessment01:17

Design Example: Analyzing Capacity Contours for Flood Risk Assessment

334
Flood risk assessment involves careful planning and analysis to ensure the safety of communities near water retention structures. Capacity contours are a vital tool in this process, as they illustrate the potential spread of water at specific levels in a given area. In the context of building a bund across a small valley, these contours play a critical role in evaluating the safety of nearby residential areas.In this example, the bund is intended to store stormwater in the valley. The engineers...
334
Relative Risk01:12

Relative Risk

2.2K
Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...
2.2K
Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

13.8K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.8K
Comparing Copy Number Variations and SNPs02:26

Comparing Copy Number Variations and SNPs

18.8K
Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
18.8K
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

6.6K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
6.6K
Comparative Excretory Systems02:24

Comparative Excretory Systems

26.7K
Animals have evolved different strategies for excretion, the removal of waste from the body. Most waste must be dissolved in water to be excreted, so an animal’s excretory strategy directly affects its water balance.
26.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Stroke-induced gut microbiome dysbiosis accelerates Alzheimer's disease progression.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism·2026
Same author

Comparative Evaluation of Metabolic Syndrome, Circadian Syndrome, and Allostatic Load Measures on All-Cause Mortality in U.S. Males and Females.

International journal of endocrinology·2026
Same author

Cognitive Fluctuations, Neuropsychiatric Burden, and Quality of Life in Moderate-Advanced Dementia With Lewy Bodies: The Role of Dysautonomia.

Neurology·2026
Same author

Analysis of reported adverse events with esophageal dilation devices: a 10-year FDA manufacturer and user facility device experience database study.

Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus·2026
Same author

Program implementation and evaluation of De Casa en Casa: a tailored community-based cervical cancer screening program for underserved Hispanic women.

Health education research·2025
Same author

Associations of mental disorders with maternal health outcomes.

Communications medicine·2025

Related Experiment Video

Updated: Feb 12, 2026

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
06:46

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Published on: September 27, 2024

926

Tailoring Colorectal Cancer Risk Assessments by Comparing Model Performance and Custom Thresholds in a Predominantly

Jennifer C Molokwu1,2,3, Alok K Dwivedi4, Jonathan D Wing3

  • 1Department of Family and Community Medicine, Center of Emphasis for Cancer, Texas Tech University Health Sciences Center El Paso, El Paso, Texas.

Cancer Prevention Research (Philadelphia, Pa.)
|February 11, 2026
PubMed
Summary
This summary is machine-generated.

This study assessed colorectal cancer (CRC) risk in Hispanic populations using four models. Freedman

More Related Videos

Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection
07:35

Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection

Published on: June 8, 2020

7.5K
Comparison of Predictive Performance of Three Lymph Node Staging Systems in Colorectal Signet Ring Cell Carcinoma Based on Machine Learning Model
07:13

Comparison of Predictive Performance of Three Lymph Node Staging Systems in Colorectal Signet Ring Cell Carcinoma Based on Machine Learning Model

Published on: April 18, 2025

758

Related Experiment Videos

Last Updated: Feb 12, 2026

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
06:46

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Published on: September 27, 2024

926
Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection
07:35

Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection

Published on: June 8, 2020

7.5K
Comparison of Predictive Performance of Three Lymph Node Staging Systems in Colorectal Signet Ring Cell Carcinoma Based on Machine Learning Model
07:13

Comparison of Predictive Performance of Three Lymph Node Staging Systems in Colorectal Signet Ring Cell Carcinoma Based on Machine Learning Model

Published on: April 18, 2025

758

Area of Science:

  • Oncology
  • Public Health
  • Epidemiology

Background:

  • Colorectal cancer (CRC) poses a significant public health challenge, especially in underserved communities.
  • Hispanic populations along the U.S.-Mexico border face unique health disparities.
  • Accurate risk assessment is crucial for effective CRC screening and prevention strategies.

Purpose of the Study:

  • To evaluate colorectal cancer (CRC) risk factors within a predominantly Hispanic cohort.
  • To compare the performance of four different CRC risk assessment models (Freedman, Wells, Kaminski, Yeoh).
  • To identify the most practical and effective model for risk stratification in this specific population.

Main Methods:

  • Analysis of data from 4,202 CRC screening participants, primarily Hispanic women.
  • Assessment of CRC risk using Freedman, Wells, Kaminski, and Yeoh models.
  • Examination of model concordance, risk distributions, and gender-specific risk trends.

Main Results:

  • Freedman's model indicated 41.1% of participants had above-average lifetime CRC risk.
  • Men showed higher lifetime risk (51.3%) while women had higher 10-year risk (26.3%).
  • Freedman and Wells models showed strong concordance (CCC = 0.76); Kaminski and Yeoh identified more high-risk individuals.

Conclusions:

  • The Freedman model is a practical tool for CRC risk assessment in this Hispanic cohort, offering both lifetime and 10-year estimates.
  • Tailored risk models and custom thresholds can improve risk stratification for enhanced screening and prevention.
  • Smoking, obesity, and family history are key CRC risk factors, with gender-specific variations.