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Related Experiment Videos

[Krattyphus].

Liv Reidun Tverelv1, Silje Lehne Michalsen2, Kirvil Thune Flygel2

  • 1Avdeling for mikrobiologi og smittevern, Universitetssykehuset Nord-Norge, Tromsø.

Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke
|February 11, 2026
PubMed
Summary

A traveler returning from Southeast Asia was diagnosed with scrub typhus, a rare rickettsial infection. Early clinical suspicion and doxycycline treatment are crucial for managing this potentially misdiagnosed condition.

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Area of Science:

  • Infectious Diseases
  • Travel Medicine
  • Rickettsiology

Background:

  • A previously healthy female presented with fever and rash after traveling in Southeast Asia.
  • The patient reported recreational activities and insect bites in rural areas.

Purpose of the Study:

  • To report a case of scrub typhus in a returning traveler.
  • To highlight the diagnostic challenges and importance of clinical suspicion for scrub typhus.

Main Methods:

  • Clinical presentation and laboratory findings were analyzed.
  • Diagnostic confirmation involved serological testing for Orientia tsutsugamushi antibodies and DNA detection from eschar tissue.
  • Empirical doxycycline treatment was initiated based on clinical suspicion.

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Main Results:

  • The patient exhibited fever, rash, eschar, leukocytosis, elevated liver enzymes, and hyponatremia.
  • Radiological imaging showed bilateral opacities and pleural effusions.
  • Scrub typhus was confirmed post-discharge by positive serology and eschar DNA.

Conclusions:

  • Scrub typhus is an uncommon but important cause of illness in travelers returning from endemic areas.
  • Non-specific symptoms can lead to misdiagnosis; prompt recognition and treatment are vital.
  • Clinician awareness is essential for timely diagnosis and management in non-endemic regions.