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Complement 3 Glomerulopathy Revisited: Bridging Pathogenesis and Therapy in the New Era
Federico Yandian1, Fernando C Fervenza2, Fernando Caravaca-Fontán3
1Department of Nephrology, Hospital de Clínicas "Dr. Manuel Quintela", Montevideo, Uruguay.
Advances in Kidney Disease and Health
|February 11, 2026
Summary
Complement 3 glomerulopathy is a rare kidney disease. New treatments offer hope, but knowledge gaps remain for managing this complex condition and preventing kidney failure.
Area of Science:
- Nephrology
- Immunology
- Genetics
Background:
- Complement 3 glomerulopathy (C3G) is a rare, heterogeneous kidney disease.
- Characterized by abnormal complement component deposition in glomeruli, leading to inflammation and kidney function decline.
- Current treatments are limited, with high rates of kidney failure and post-transplant recurrence.
Purpose of the Study:
- To review the heterogeneity of C3G.
- To examine emerging therapeutic strategies.
- To highlight advancements in managing C3G.
Main Methods:
- Literature review of C3G pathophysiology, genetics, and treatment trials.
- Analysis of current therapeutic options and their outcomes.
- Discussion of knowledge gaps and future directions.
Main Results:
- C3G exhibits significant heterogeneity in pathophysiology, with genetic variants and autoantibodies playing roles.
- Despite limited current treatments, recent clinical trials show promising results.
- Significant knowledge gaps persist in understanding and managing C3G.
Conclusions:
- C3G management requires addressing its heterogeneous nature.
- Emerging therapies offer potential for improved patient outcomes.
- Further research is crucial to overcome knowledge gaps and optimize C3G treatment.
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